Role of Gasotransmitters in Inflammatory Edema

Autor(es)

Coavoy-Sanchez, Silvia Abigail ; Marques, Leonardo Andre da Costa ; Costa, Soraia Katia Pereira ; Muscara, Marcelo Nicolas

• Tipo de documento: Artigo Científico
• Fonte: Antioxidants & Redox Signaling; v. N/A, p. 20-pg., 2023-05-23.

Resumo

Significance: Nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) are, to date, the identified members of the gasotransmitter family, which consists of gaseous signaling molecules that play central roles in the regulation of a wide variety of physiological and pathophysiological processes, including inflammatory edema. Recent Advances: Recent studies show the potential anti-inflammatory and antiedematogenic effects of NO-, CO-, and H2S-donors in vivo. In general, it has been observed that the therapeutical effects of NO-donors are more relevant when administered at low doses at the onset of the inflammatory process. Regarding CO-donors, their antiedematogenic effects are mainly associated with inhibition of proinflammatory mediators (such as inducible NO synthase [iNOS]-derived NO), and the observed protective effects of H2S-donors seem to be mediated by reducing some proinflammatory enzyme activities. Critical Issues: The most recent investigations focus on the interactions among the gasotransmitters under different pathophysiological conditions. However, the biochemical/pharmacological nature of these interactions is neither general nor fully understood, although specifically dependent on the site where the inflammatory edema occurs. Future Directions: Considering the nature of the involved mechanisms, a deeper knowledge of the interactions among the gasotransmitters is mandatory. In addition, the development of new pharmacological tools, either donors or synthesis inhibitors of the three gasotransmitters, will certainly aid the basic investigations and open new strategies for the therapeutic treatment of inflammatory edema. (AU)

• Processo FAPESP: 13/04151-3 - Avaliação farmacológica dos doadores de H2S (de liberação lenta e rápida) no comportamento de prurido e inflamação relacionada em pele de camundongos
• Beneficiário: Soraia Katia Pereira Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/24518-1 - Papel do sulfeto de hidrogênio (H2S) nas respostas inflamatória e nociceptiva induzidas por carragenina na articulação temporomandibular de ratos
• Beneficiário: Marcelo Nicolas Muscara
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/16409-6 - Efeito de compostos doadores de sulfeto de hidrogênio (H2S) na dermatite atópica experimental induzida em camundongos.
• Beneficiário: Silvia Abigail Coavoy Sanchez
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/14051-2 - Estudo sobre a participação e efeitos do sulfeto de hidrogênio (H2S) na resposta vasomotora in vitro da artéria mesentérica de camundongos
• Beneficiário: Marcelo Nicolas Muscara
• Modalidade de apoio: Auxílio à Pesquisa - Regular