Efficacy and Safety of 2% and 4% Articaine for Lower Third Molar Surgery

Autor(es)

Senes, A. M. ; Calvo, A. M. ; Colombini-Ishikiriama, B. L. ; Goncalves, P. Z. ; Dionisio, T. J. ; Sant'ana, E. ; Brozoski, D. T. ; Lauris, J. R. P. ; Faria, F. A. C. ; Santos, C. F.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF DENTAL RESEARCH; v. 94, n. 9, p. 8-pg., 2015-09-01.

Resumo

This double-blind crossover randomized clinical trial compared the efficacy of 2 concentrations of articaine, 2% (A2) and 4% (A4), with 1:200,000 epinephrine, for lower third molar removal. During 2 separate appointments with either A2 or A4, both similarly positioned lower third molars in 46 volunteers were extracted. The following were evaluated: onset and duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative analgesia, and mouth opening and wound healing during the 7th postoperative day, along with the incidence, type, and severity of adverse reactions. Nearly identical volumes of both anesthetic solutions were used for each appointment: 3.4 +/- 0.9 mL approximate to 68 mg of articaine (A2) and 3.3 +/- 0.8 mL approximate to 132 mg of articaine (A4). Statistical analysis indicated no differences in onset or duration of anesthetic action on soft tissues or duration of postoperative analgesia evoked by A2 and A4 anesthetic solutions (P > 0.05). The surgeon's rating of intraoperative bleeding was considered minimal throughout all surgery with both anesthetic solutions. While transient changes in blood pressure, heart rate, and oxygen saturation were observed, these factors were clinically insignificant and were uninfluenced by articaine concentration (P > 0.05). No systemic or local adverse reactions were observed in the preoperative and postoperative periods due to A2 or A4, but 1 case of bilateral paresthesia was observed. There were no significant differences between preoperative and postoperative (7th day) values of mouth opening and wound healing whether volunteers received A2 or A4 (P > 0.05). In conclusion, both A2 and A4, administered in equal volumes, were effective and safe during lower third molar surgery, and no significant differences were found between their efficacy and safety (ClinicalTrials.gov NCT02457325). (AU)

• Processo FAPESP: 09/15372-5 - Interação entre o sistema renina-angiotensina e o fator de crescimento endotelial na doença periodontal induzida experimentalmente em ratos
• Beneficiário: Daniel Thomas Brozoski
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 10/16985-8 - 1) Análise comparativa entre articaína 2% e articaína 4% ambas com adrenalina 1:200.000: avaliação da eficácia anestésica, sangramento intra-operatório e parâmetros hemodinâmicos em exodontias de terceiros molares inferiores, e 2) Avaliação da eficácia clínica do piroxicam administrado por via oral e sublingual para o controle da dor, edema e trismo após exodontia de terceiros molares inferiores
• Beneficiário: Carlos Ferreira dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/17851-8 - Influência do genótipo do citocromo P450 (CYP2C9) na eficácia clínica e farmacocinética do piroxicam após cirurgias de terceiros molares inferiores
• Beneficiário: Adriana Maria Calvo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado