Anti-Mycobacterium tuberculosis activity of platinum(II)/N,N-disubstituted-N '-acyl thiourea complexes

Autor(es)

Plutin, Ana M. ; Alvarez, Anislay ; Mocelo, Raul ; Ramos, Raul ; Castellano, Eduardo E. ; da Silva, Monize M. ; Colina-Vegas, Legna ; Pavan, Fernando R. ; Batista, Alzir A.

• Tipo de documento: Artigo Científico
• Fonte: Inorganic Chemistry Communications; v. 63, p. 7-pg., 2016-01-01.

Resumo

Synthesis, characterization and anti-Mycobacterium tuberculosis assays of new platinum(II)/dppf/N,N-disubstituted-N'-acyl thiourea complexes with general formulae [Pt(dppf)(L)]PF6, [dppf = 1,1'-bis (diphenylphosphino)ferrocene; L = N,N-disubstituted-N'-acyl thioureas] is reported. The complexes were characterized by elemental analysis, molar conductivity, IR, NMR (H-1, C-13 and P-31{H-1}) spectroscopy. The spectroscopic data are consistent with the complexes containing one dppf and one O, S chelated ligand. The crystal structures of complexes with N,N-diphenyl-N'-benzoylthiourea (L4), N,N-diethyl-N'-furoylthiourea (L5) and N,N-diphenyl-N'-(thiophene-2-carbonyl)thiourea (L8) were determined by X-ray crystallography, confirming the coordination of the ligands with the metal through sulfur and oxygen atoms, forming distorted square-planar structures. The complexes were screened with respect to their anti-M. tuberculosis activity (H37Rv ATCC 27294). (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/14957-5 - Investigação do potencial contra tuberculose de uma nova classe de compostos furoxânicos e compostos nanoestruturados de rutênio(II) e cobre(II)
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 14/13691-4 - A cristalografia como ferramenta no auxílio para a elucidação do mecanismo de ação de potenciais metalofármacos
• Beneficiário: Eduardo Ernesto Castellano
• Modalidade de apoio: Auxílio à Pesquisa - Regular