| Texto completo | |
| Autor(es): |
Santos, Tiago Goss
;
Martins, Vilma Regina
;
Maroso Hajj, Glaucia Noeli
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 18, n. 5, p. 17-pg., 2017-05-01. |
| Resumo | |
Heat shock proteins (HSPs) are abundant cellular proteins involved with protein homeostasis. They have both constitutive and inducible isoforms, whose expression levels are further increased by stress conditions, such as temperature elevation, reduced oxygen levels, infection, inflammation and exposure to toxic substances. In these situations, HSPs exert a pivotal role in offering protection, preventing cell death and promoting cell recovery. Although the majority of HSPs functions are exerted in the cytoplasm and organelles, several lines of evidence reveal that HSPs are able to induce cell responses in the extracellular milieu. HSPs do not possess secretion signal peptides, and their secretion was subject to widespread skepticism until the demonstration of the role of unconventional secretion forms such as exosomes. Secretion of HSPs may confer immune system modulation and be a cell-to-cell mediated form of increasing stress resistance. Thus, there is a wide potential for secreted HSPs in resistance of cancer therapy and in the development new therapeutic strategies. (AU) | |
| Processo FAPESP: | 15/02098-3 - Papel da stress inducible protein 1 (STI1) no desenvolvimento vascular embrionário e na angiogênese tumoral |
| Beneficiário: | Tiago Góss dos Santos |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/15550-9 - Controle traducional no câncer |
| Beneficiário: | Glaucia Noeli Maroso Hajj |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 09/14027-2 - Mecanismos associados à função da proteína prion e seu ligante STI1/Hop: abordagens terapêuticas |
| Beneficiário: | Vilma Regina Martins |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |