Assembly of a PDT device with a near-infrared fluorescence monitoring of PpIX during treatment

Autor(es)

Garcia, Marlon R. ; Pratavieira, Sebastiao ; Moriyama, Lilian T. ; Kurachi, Cristina ; Magalhaes, Daniel V. ; Kessel, DH ; Hasan, T

• Tipo de documento: Artigo Científico
• Fonte: OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXVIII; v. 10860, p. 7-pg., 2019-01-01.

Resumo

This paper describes the assembly and characterization of a system to treat and monitor ALA-based photodynamic therapy, using near-infrared fluorescence images for photosensitizer monitoring. The system is portable, user friendly and low cost, using a diode laser emitting at 633 nm as treatment light, capable to delivery up to 150 mW/cm(2) at the lesion surface. The PpIX fluorescence is excited by the treatment light itself, and detected by camera in real-time. Since the excitation and emission wavelengths are in the red-NIR spectral regions, the penetration into the skin is improved and the volume measured by the fluorescence images is larger when compared to the widely used violet excitation. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50857-8 - INCT 2014 - de Óptica Básica e Aplicada às Ciências da Vida
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Temático