Lithium and disease modification: A systematic review and meta-analysis in Alzheimer's and Parkinson's disease

Autor(es)

Singulani, Monique Patricio ; Ferreira, Ana Flavia Fernandes ; Figueroa, Paulina Sepulveda ; Cuyul-Vasquez, Ivan ; Talib, Leda Leme ; Britto, Luiz Roberto ; Forlenza, Orestes Vicente

• Tipo de documento: Artigo Científico
• Fonte: AGEING RESEARCH REVIEWS; v. 95, p. 20-pg., 2024-02-24.

Resumo

The role of lithium as a possible therapeutic strategy for neurodegenerative diseases has generated scientific interest. We systematically reviewed and meta-analyzed pre-clinical and clinical studies that evidenced the neuroprotective effects of lithium in Alzheimer's (AD) and Parkinson's disease (PD). We followed the PRISMA guidelines and performed the systematic literature search using PubMed, EMBASE, Web of Science, and Cochrane Library. A total of 32 articles were identified. Twenty-nine studies were performed in animal models and 3 studies were performed on human samples of AD. A total of 17 preclinical studies were included in the meta-analysis. Our analysis showed that lithium treatment has neuroprotective effects in diseases. Lithium treatment reduced amyloid-beta and tau levels and significantly improved cognitive behavior in animal models of AD. Lithium increased the tyrosine hydroxylase levels and improved motor behavior in the PD model. Despite fewer clinical studies on these aspects, we evidenced the positive effects of lithium in AD patients. This study lends further support to the idea of lithium's therapeutic potential in neurodegenerative diseases. (AU)

• Processo FAPESP: 20/02109-3 - Participação do canal TRPM2 na neurodegeneração e ativação microglial no modelo da Doença de Parkinson induzido por 6-hidroxidopamina
• Beneficiário: Ana Flávia Fernandes Ferreira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/06378-1 - Análise do envolvimento do lítio nos marcadores mitocondriais na Doença de Alzheimer
• Beneficiário: Monique Patricio Singulani
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50873-3 - INCT 2014: Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN)
• Beneficiário: Wagner Farid Gattaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático