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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

beta IIPKC and epsilon PKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure

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Autor(es):
Batista Ferreira, Julio Cesar [1, 2] ; Brum, Patricia Chakur [2] ; Mochly-Rosen, Daria [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, CCSR, Stanford, CA 94305 - USA
[2] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY; v. 51, n. 4, p. 479-484, OCT 2011.
Citações Web of Science: 31
Resumo

Cardiac hypertrophy is a complex adaptive response to mechanical and neurohumoral stimuli and under continual stressor, it contributes to maladaptive responses, heart failure and death. Protein kinase C (PKC) and several other kinases play a role in the maladaptative cardiac responses, including cardiomyocyte hypertrophy, myocardial fibrosis and inflammation. Identifying specific therapies that regulate these kinases is a major focus of current research. PKC, a family of serine/threonine kinases, has emerged as potential mediators of hypertrophic stimuli associated with neurohumoral hyperactivity in heart failure. In this review, we describe the role of PKC isozymes that is involved in cardiac hypertrophy and heart failure. This article is part of a special issue entitled ``Key Signaling Molecules in Hypertrophy and Heart Failure{''}. (C) 2010 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 09/03143-1 - Controle de qualidade de proteína na insuficiência cardíaca: papel das diferentes isoformas de proteína quinase C
Beneficiário:Julio Cesar Batista Ferreira
Linha de fomento: Bolsas no Brasil - Pós-Doutorado