Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress

Autor(es)

Granjeiro, Erica M. ^[1] ; Gomes, Felipe V. ^[2] ; Guimaraes, Francisco S. ^[2] ; Correa, Fernando M. A. ^[2] ; Resstel, Leonardo B. M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Physiol, Sch Med, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Dept Pharmacol, Sch Med, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Pharmacology Biochemistry and Behavior; v. 99, n. 4, p. 743-748, OCT 2011.
• Citações Web of Science: 19

Resumo

Systemic administration of cannabidiol (CBD), a non-psychotomimetic compound from Cannabis sativa, attenuates the cardiovascular and behavioral responses to restraint stress. Although the brain structures related to CBD effects are not entirely known, they could involve brainstem structures responsible for cardiovascular control. Therefore, to investigate this possibility the present study verified the effects of CBD (15.30 and 60 nmol) injected into the cisterna magna on the autonomic and behavioral changes induced by acute restraint stress. During exposure to restraint stress (1 h) there was a significant increase in mean arterial pressure (MAP) and heart rate (HR). Also, 24 h later the animals showed a decreased percentage of entries onto the open arms of the elevated plus-maze. These effects were attenuated by CBD (30 nmol). The drug had no effect on MAP and HR baseline values. These results indicate that intracisternal administration of CBD can attenuate autonomic responses to stress. However, since CBD decreased the anxiogenic consequences of restraint stress, it is possible that the drug is also acting on forebrain structures. (C) 2011 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 07/03685-3 - Neurotransmissores típicos e atípicos em transtornos neuropsiquiátricos
• Beneficiário: Francisco Silveira Guimaraes
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 09/08647-8 - Função do núcleo paraventricular do hipotálamo na resposta cardiovascular e neuroendócrina observada em ratos submetidos ao estresse por restrição
• Beneficiário: Erica Maria Granjeiro
• Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 10/17343-0 - Avaliação dos efeitos do canabidiol sobre as alterações comportamentais e moleculares induzidas pelo tratamento repetido com MK-801
• Beneficiário: Felipe Villela Gomes
• Linha de fomento: Bolsas no Brasil - Doutorado