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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ethanol consumption and pineal melatonin daily profile in rats

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Autor(es):
Peres, Rafael [1] ; do Amaral, Fernanda Gaspar [1] ; Madrigrano, Thiago Cardoso [1] ; Scialfa, Julieta Helena [1] ; Bordin, Silvana [1] ; Afeche, Solange Castro ; Cipolla-Neto, Jose [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: ADDICTION BIOLOGY; v. 16, n. 4, p. 580-590, OCT 2011.
Citações Web of Science: 15
Resumo

It is well known that melatonin participates in the regulation of many important physiological functions such as sleep-wakefulness cycle, motor coordination and neural plasticity, and cognition. However, as there are contradictory results regarding the melatonin production diurnal profile under alcohol consumption, the aim of this paper was to study the phenomenology and mechanisms of the putative modifications on the daily profile of melatonin production in rats submitted to chronic alcohol intake. The present results show that rats receiving 10% ethanol in drinking water for 35 days display an altered daily profile of melatonin production, with a phase delay and a reduction in the nocturnal peak. This can be partially explained by a loss of the daily rhythm and the 25% reduction in tryptophan hydroxylase activity and, mainly, by a phase delay in arylalkylamine N-acetyltransferase gene expression and a 70% reduction in its peak activity. Upstream in the melatonin synthesis pathway, the results showed that noradrenergic signaling is impaired as well, with a decrease in beta 1 and alpha 1 adrenergic receptors' mRNA contents and in vitro sustained loss of noradrenergic-stimulated melatonin production by glands from alcohol-treated rats. Together, these results confirm the alterations in the daily melatonin profile of alcoholic rats and suggest the possible mechanisms for the observed melatonin synthesis modification. (AU)

Processo FAPESP: 07/01416-5 - Influência do alcoolismo na fisiologia da glândula pineal e na transcrição dos genes relógio pelo núcleo supraquiasmático
Beneficiário:Rafael Peres
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 04/06767-2 - O papel da melatonina no controle do metabolismo energético: interações hormonais, ações centrais e periféricas (pineal, obesidade, diabetes e envelhecimento)
Beneficiário:José Cipolla Neto
Linha de fomento: Auxílio à Pesquisa - Temático