Myeloproliferative Neoplasms Transcriptome Reveals Pro-Inflammatory Signature and Enrichment in Peripheral Blood Monocyte-Related Genes

Autor(es)

Bassan, Vitor Leonardo ; de Freitas Martins Felicio, Rafaela ; de Farias, Kelen Cristina Ribeiro Malmegrim ; de Castro, Fabiola Attie

• Tipo de documento: Artigo Científico
• Fonte: CANCER INVESTIGATION; v. 42, n. 7, p. 14-pg., 2024-07-02.

Resumo

Myeloproliferative neoplasms (MPN) are hematological diseases associated with genetic driver mutations in the JAK2, CALR, and MPL genes and exacerbated oncoinflammatory status. Analyzing public microarray data from polycythemia vera (n = 41), essential thrombocythemia (n = 21), and primary myelofibrosis (n = 9) patients' peripheral blood by in silico approaches, we found that pro-inflammatory and monocyte-related genes were differentially expressed in MPN patients' transcriptome. Genes related to cell activation, secretion of pro-inflammatory and pro-angiogenic mediators, activation of neutrophils and platelets, coagulation, and interferon pathway were upregulated in monocytes compared to controls. Together, our results suggest that molecular alterations in monocytes may contribute to oncoinflammation in MPN. (AU)

• Processo FAPESP: 19/18013-8 - Caracterização imunofenotípica e molecular de subpopulações de monócitos em neoplasias mieloproliferativas
• Beneficiário: Vitor Leonardo Bassan
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/08135-2 - CTC - Centro de Terapia Celular
• Beneficiário: Dimas Tadeu Covas
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/19714-7 - Influência das alterações das células estromais mesenquimais multipotentes da medula óssea na fisiopatologia e progressão das neoplasias mieloproliferativas BCR-ABL1-
• Beneficiário: Fabíola Attié de Castro
• Modalidade de apoio: Auxílio à Pesquisa - Regular