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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model

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Autor(es):
Matsuo, Alisson L. [1] ; Figueiredo, Carlos R. [1] ; Arruda, Denise C. [1] ; Pereira, Felipe V. [1] ; Bonin Scutti, Jorge A. [1] ; Massaoka, Mariana H. [1] ; Travassos, Luiz R. [1] ; Sartorelli, Patricia [2] ; Lago, Joao H. G. [2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Micro Imuno & Parasitol, Disciplina Biol Celular, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Biochemical and Biophysical Research Communications; v. 411, n. 2, p. 449-454, JUL 29 2011.
Citações Web of Science: 62
Assunto(s):Melanoma   Apoptose
Resumo

Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance to conventional drugs mainly by deregulation of apoptotic pathways. The aim of this work was to investigate the cell death mechanism induced by alpha-pinene and its therapeutic application. Our results demonstrated that alpha-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface. Most importantly, this molecule was very effective in the treatment of experimental metastatic melanoma reducing the number of lung tumor nodules. This is the first report on the apoptotic and antimetastatic activity of isolated alpha-pinene. (C) 2011 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 08/51256-7 - Peptídeos e derivados baseados na estrutura de CDRs de imunoglobulinas: atividade anti-tumoral de mAbc C7 H2 e MAb hua L1 anti-melanoma (b16f-10-nex2 e melanoma humano) e anti-leucemia (HL-60) in vitro e in vivo e possíveis mecanismos de ação
Beneficiário:Denise Costa Arruda
Linha de fomento: Bolsas no Brasil - Pós-Doutorado