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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss

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Autor(es):
Damaso, Ana R. [1, 2] ; de Piano, Aline [3] ; Sanches, Priscila L. [3] ; Corgosinho, Flavia [3] ; Tock, Lian [3] ; Oyama, Lila M. [4] ; Tock, Luciana [5] ; Oller do Nascimento, Claudia M. [4] ; Tufik, Sergio [6] ; de Mello, Marco Tulio [6]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Interdisiciplinary Hlth Sci, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Dept Biosci, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Nutr, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Dept Physiol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Dept Endocrinol, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Dept Psychobiol, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Peptides; v. 32, n. 7, p. 1384-1391, JUL 2011.
Citações Web of Science: 24
Resumo

Leptin has emerged over the past decade as a key hormone not only in energy balance regulation but also in neuroendocrine and inflammatory processes. The aim of the present study was to evaluate whether hyperleptinemia deregulates neuropeptides during weight loss. A total of 86 post-pubertal obese adolescents (with or without hyperleptinemia) participated in one year of interdisciplinary weight loss therapy (clinical, nutritional, psychological and exercise-related). Adipokine and neuropeptide concentrations were measured by ELISA, visceral fat was measured by ultrasound and body composition was measured by pletismography. The hyperleptinemic patients presented a lower alpha-MSH concentration and higher NPY/AgRP ratio while the adiponectin/leptin (A/L) ratio was lower compared with the non-hyperleptinemic group. After therapy, significant improvements in BM, BMI, body fat mass, visceral and subcutaneous fat, HOMA-IR, QUICKI, total cholesterol and triglycerides were observed in both groups. Indeed, we observed significant increases in adiponectin and A/L as well as reductions in leptin and NPY/AgRP ratio in the hyperleptinemic group. In the stepwise multiple linear regression analysis with leptin concentration as the dependent variable, alpha-MSH and body fat mass (%) were the independent predictors to explain leptin concentration. For the entire group, we found positive correlations between leptinemia and BMI and body fat mass (%) as well as a negative correlation with free fat mass (%) and alpha-MSH. Finally, we verified negative correlations between adiponectin/leptin ratio with total cholesterol and LDL-c, only in hyperleptinemic patients. In conclusion, the hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss. (C) 2011 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular