| Texto completo | |
| Autor(es): |
Veiga, A. C.
;
Silva-Aguiar, R. P.
;
Milanez, M. I. O.
;
Aires, R. S.
;
Moraes, Y. A. C.
;
Campos, R. R.
;
Bergamaschi, C. T.
;
Caruso-Neves, C.
;
Nishi, E. E.
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | HYPERTENSION RESEARCH; v. N/A, p. 12-pg., 2025-01-17. |
| Resumo | |
Proteinuria, especially albuminuria, serves as an independent risk factor for progression in cardiovascular and renal diseases. Clinical and experimental studies have demonstrated that renal nerves contribute to renal dysfunction in arterial hypertension (AH). This study hypothesizes that renal nerves mediate the mechanisms of protein endocytosis by proximal tubule epithelial cells (PTEC) and glomerular function; with dysregulation of the renal nerves contributing to proteinuria in Wistar rats with renovascular hypertension (2-kidney, 1-clip model, 2K-1C). Reduced albumin uptake and increased internalization of endocytic receptor megalin in PTEC were found in both the clipped and contralateral kidneys of 2K-1C rats. Renal denervation (DNx) or hydralazine treatment restored these parameters. Moreover, DNx, but not hydralazine, reduced serum creatinine and recovered podocyte numbers in the contralateral kidney of 2K-1C rats. Thus, our data suggest that renal nerves and high arterial pressure contribute to decreased albumin reabsorption by cellular redistribution of megalin in PTEC, while renal nerves remarkably drive glomerular dysfunction in renovascular hypertension, independently of their effect on blood pressure.Created with BioRender.com (AU) | |
| Processo FAPESP: | 19/25295-0 - Comunicação entre o sistema nervoso central e rins: influências cardiovasculares, renais e autonômicas em condições fisiológicas e fisiopatológicas |
| Beneficiário: | Ruy Ribeiro de Campos Junior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 22/11063-2 - Efeitos do transplante de medula óssea com alta expressão mieloide de ECA no metabolismo do tecido adiposo e parâmetros cardiovasculares em camundongos obesos |
| Beneficiário: | Erika Emy Nishi |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |
| Processo FAPESP: | 20/02617-9 - Mecanismos envolvidos na reabsorção renal de proteínas na Hipertensão Renovascular: papel do nervo renal |
| Beneficiário: | Amanda Costa Veiga |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |