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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cellular death but not genetic damage in oral mucosa cells after exposure to digital lateral radiography

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Autor(es):
Ribeiro, Daniel A. [1, 2] ; Sannomiya, Eduardo K. [3, 4] ; Pozzi, Renan [1] ; Miranda, Sandra R. [2] ; Angelieri, Fernanda [3]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, BR-11060001 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Patol, Sao Paulo - Brazil
[3] Sao Paulo Methodist Univ, Dept Orthodont, UMESP, Sao Paulo - Brazil
[4] Sao Paulo Methodist Univ, Dept Dentomaxillofacial Radiol, UMESP, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: CLINICAL ORAL INVESTIGATIONS; v. 15, n. 3, p. 357-360, JUN 2011.
Citações Web of Science: 9
Resumo

The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated buccal mucosa cells from individuals following digital lateral radiography. A total of 30 healthy patients (15 men and 15 women) indicated to the orthodontic therapy were submitted to digital lateral X-ray. Exfoliated oral mucosa cells were collected immediately before the X-ray exposure and after 10 days. The results pointed out no significant statistically differences (p > 0.05) of micronucleated oral mucosa cells. On the other hand, X-ray was able to increase other nuclear alterations closely related to cytotoxicity such as karyorrhexis, pyknosis, and karyolysis. In summary, these data indicate that exposure to digital lateral radiography may not be a factor that induced chromosomal damage, but it is able to promote cytotoxicity. (AU)

Processo FAPESP: 07/01228-4 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
Beneficiário:Daniel Araki Ribeiro
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores