| Texto completo | |
| Autor(es): |
Oliveira, Akila Lara
;
Medeiros, Matheus Leite
;
Campos, Antonio Thiago Pereira
;
Cesar, Carlos Lenz
;
Monica, Fabiola Zakia
;
Antunes, Edson
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ANTIOXIDANTS; v. 14, n. 7, p. 20-pg., 2025-06-27. |
| Resumo | |
The advanced glycation end product (AGE)-RAGE axis has been implicated in the pathophysiology of diabetic bladder dysfunction (DBD). However, no previous studies have explored the effects of RAGE blockade on this condition. Here, we explored the effects of the selective RAGE inhibitor TTP488 (azeliragon) at the functional and molecular levels of bladder dysfunction in ob/ob leptin-deficient mice. Female B6.V-Lep ob/JUnib (ob/ob) and wild-type (WT) C57BL/6 mice were used as lean controls. Treatment with TTP488 in ob/ob mice resulted in no changes in body weight, fasting glucose, or insulin resistance; however, it reduced total AGE and MG-H1 levels without altering RAGE levels in bladder tissues. TTP488 normalized glyoxalase-1, glutathione reductase, glutathione peroxidase, and superoxide dismutase activities in bladder tissues. Marked increases in collagen intensity were also observed in ob/ob mice, an effect fully reversed by TTP488 treatment. TTP488 reduced total void volume, volume per void, and ex vivo bladder contractility in response to electrical-field stimulation and carbachol. Our finding that TTP488 mitigates DBD in ob/ob mice supports the proposal that RAGE blockade could serve as a promising therapeutic strategy for managing DBD. (AU) | |
| Processo FAPESP: | 23/09353-5 - Papel do receptor para Produtos Finais de Glicação Avançada(AGEr) na disfunção da bexiga diabética:Um novo alvo terapêutico? |
| Beneficiário: | Ákila Lara de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 24/10306-4 - Eixo metilglioxal - produtos finais de glicação avançada (AGEs) - receptor para AGEs (AGEr): Potencial alvo terapêutico para prevenção e tratamento da disfunção vesical associada a obesidade e diabetes |
| Beneficiário: | Edson Antunes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |