Busca avançada
Ano de início
Entree


Improved Synthesis of 5-Nitrohomovanillic Acid and 6-Nitrohomovanillic Acid as Probes for Metabolism Studies of Endothelium-Derived Dopamines: Identification in Human Amniotic Fluid

Texto completo
Autor(es):
Mostrar menos -
Sparaco, Rosa ; Cinque, Pierfrancesco ; Scognamiglio, Antonia ; Vertuccio, Stefania ; Caliendo, Giuseppe ; Fiorino, Ferdinando ; Corvino, Angela ; Magli, Elisa ; Perissutti, Elisa ; Santagada, Vincenzo ; Severino, Beatrice ; Andreozzi, Giorgia ; Luciano, Paolo ; Dell'aversano, Carmela ; Miller, Alex Henrique ; De Nucci, Gilberto ; Frecentese, Francesco
Número total de Autores: 17
Tipo de documento: Artigo Científico
Fonte: Molecules; v. 30, n. 20, p. 17-pg., 2025-10-15.
Resumo

6-Nitrodopamine is an endogenous catecholamine responsible for numerous biological activities. Here, an improved method for the synthesis of both 6-nitrohomovanillic acid (6-NHVA) and its regioisomer 5-nitrohomovanillic acid (5-NHVA) is reported. The developed one-step synthetic procedures ensured the efficient preparation of the target compounds in good yields. Comprehensive structural characterization was achieved through one- and two-dimensional NMR studies and by high-resolution mass spectrometry (HR-MS/MS). The presence of both substances was identified in human amniotic fluid by LC-MS/MS. (AU)

Processo FAPESP: 19/16805-4 - Avaliação do papel fisiopatológico das catecolaminas endoteliais
Beneficiário:Gilberto de Nucci
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 24/08067-1 - Avaliação da estabilidade de novas catecolaminas endógenas em líquidos biológicos e identificação de possíveis metabólitos
Beneficiário:Alex Henrique Miller
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado