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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

CHARACTERIZATION OF CLASS 1 INTEGRONS AND ANTIBIOTIC RESISTANCE GENES IN MULTIDRUG-RESISTANT SALMONELLA ENTERICA ISOLATES FROM FOODSTUFF AND RELATED SOURCES

Autor(es):
Ribeiro, Vinicius B. [1] ; Lincopan, Nilton [2] ; Landgraf, Mariza [1] ; Franco, Bernadete D. G. M. [1] ; Destro, Maria T. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Alimentos & Nutr Expt, Fac Farm, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Microbiol, Inst Ciencias Biomed, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Microbiology; v. 42, n. 2, p. 685-692, APR-JUN 2011.
Citações Web of Science: 17
Resumo

In recent years, an increase in the occurrence of antimicrobial resistance among Salmonella enterica has been observed in several countries, which is worrisome because S. enterica is one of the most common causes of human gastroenteritis worldwide. The aim of this study was to characterize class 1 integrons and antibiotic resistance genotypes in Salmonella enterica isolates recovered from foodstuff and related sources. Nineteen multidrug-resistant (MDR) Salmonella enterica isolates were recovered. Higher resistance rates to tetracycline (90%), streptomycin (80%), sulfamethoxazole-trimethoprim (80%), ampicillin (60%) and nalidixic acid (70%) were related to the presence of the tetA, aadA, sul1/sul2, bla(TEM-1) genes, and a codon mutation at position 83 of the gyrA gene, respectively. Class 1 integrons harboring aadA, bla(TEM-1), sul1 or dhfr1 genes were detected in nine (45%) Salmonella enterica strains belonging to serotypes Brandenburg, Panama, Agona, Mbandaka and Alachua. Finally, clonal dissemination of S. Panama, S. Derby and S. Mbandaka was confirmed by PFGE. Detection of clonally related MDR Salmonella enterica suggests that endemic serotypes can be supported by class 1 integron-borne gene cassettes and/or mutations in drug targets. Emergence and dissemination of multidrug-resistant Salmonella enterica can have a major public health impact in an environment where large-scale suppliers ship their products. (AU)

Processo FAPESP: 05/57779-3 - Caracterização de determinantes de virulência, integrons e genes para resistência a antimicrobianos de cepas de Salmonella enterica isoladas de alimentos e fontes relacionadas
Beneficiário:Vinicius Buccelli Ribeiro
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 06/50813-4 - Caracterização de integrons, genes para resistência e antimicrobianos e determinantes de virulência de cepas de Salmonella enterica isoladas de alimentos e fontes relacionadas
Beneficiário:Maria Teresa Destro
Linha de fomento: Auxílio à Pesquisa - Regular