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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Penile anthropometry in systemic lupus erythematosus patients

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Autor(es):
Vecchi, A. P. ; Borba, E. F. ; Bonfa, E. ; Cocuzza, M. [1] ; Pieri, P. [2] ; Kim, C. A. [3] ; Silva, C. A. [4, 5]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Dept Urol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Pediat Dept Lab, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Clin Genet Unit, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Disciplina Reumatol, Div Rheumatol, Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Pediat Rheumatol Unit, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Lupus; v. 20, n. 5, p. 512-518, APR 2011.
Citações Web of Science: 13
Resumo

The aim of this study was to evaluate penile anthropometry in systemic lupus erythematosus (SLE) patients compared with healthy controls and the possible relevant pubertal, clinical, hormonal and treatment factors that could influence penile dimensions. Twenty-five consecutive SLE patients were assessed by urological examination, sexual function, testicular ultrasound, hormones, sperm analysis, genetic analysis, clinical features and treatment. The control group included 25 age-matched healthy males. SLE patients had a lower median penis length and circumference {[}8 (7.5-10) vs. 10 (8-13) cm, p = 0.0001; 8 (7-10) vs. 10 (7-11) cm, p = 0.001; respectively], lower median testicular volume by right and left Prader {[}15 (10-25) vs. 20 (12-25) ml, p = 0.003; 15 (10-25) vs. 20 (12-25) ml, p = 0.006; respectively], higher median of follicle-stimulating hormone {[}5.8 (2.1-25) vs. 3.3 (1.9-9) IU/l, p = 0.002] and lower morning total testosterone levels (28% vs. 0%, p = 0.009) compared with controls. In spite of that, erectile dysfunction was not observed in patients or controls. Analyses of lupus patients revealed that the median penis circumference was lower in patients with disease onset before first ejaculation compared with those with disease onset after first ejaculation {[}7.8 (7-10) vs. 9.0 (7.5-10) cm, p = 0.026]. No differences were observed in the median penile anthropometry regarding sexual dysfunction (p = 0.610), lower morning total testosterone levels (p = 0.662), oligo/azoospermia (p = 0.705), SLE Disease Activity Index >= 4 (p = 0.562), Systemic Lupus International Collaborating Clinics/ACR Damage Index >= 1 (p = 0.478), prednisone cumulative dose (p = 0.789) and intravenous cyclophosphamide therapy (p = 0.754). Klinefelters syndrome (46XY/47XXY) was diagnosed in one (4%) SLE patient with decreased penile size whereas Y-chromosomal microdeletions was absent in all of them. In conclusion, we have identified reduced penile dimensions in SLE patients with no deleterious effect in erectile function. Disease onset before first ejaculation seems to affect penis development in pre-pubertal lupus. Lupus (2011) 20, 512-518. (AU)

Processo FAPESP: 05/56482-7 - Avaliação da função gonadal em pacientes do sexo masculino com dermatomiosite e polimiosite
Beneficiário:Clovis Artur Almeida da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 04/07832-2 - Avaliação da função gonadal em pacientes do sexo masculino com lúpus eritematoso sistêmico
Beneficiário:Clovis Artur Almeida da Silva
Linha de fomento: Auxílio à Pesquisa - Regular