| Texto completo | |
| Autor(es): |
Hi, E. M. B.
;
Bianchi, C. C. R.
;
Gritte, R. B.
;
Klauss, P. H. A.
;
Leal, N. F. S. M.
;
de Oliveira, I. S.
;
de Barros, M. F. C. B.
;
Soriano, F. G.
;
Curi, R.
;
Machado, M. C. C.
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Brazilian Journal of Medical and Biological Research; v. 58, p. 11-pg., 2025-01-01. |
| Resumo | |
After SARS-CoV-2 infection, severe COVID-19 may develop with persistent sequelae, even after hospital discharge. This condition may result from tissue damage or immune alterations caused by the virus, including immune dysregulation, hyperinflammation, loss of immune tolerance, excessive neutrophil extracellular trap (NET) production, and antibody cross-reactivity (molecular mimicry), which can promote autoantibody development. This study evaluated autoantibody expression in patients with long COVID-19 and its potential relationship with symptoms. Conducted in Baixada Santista, S & atilde;o Paulo, Brazil, the study involved 55 participants aged 21-85 years who had tested positive for SARS-CoV-2. Blood samples were collected two years post-discharge, and serum was analyzed for inflammatory and autoimmune markers, including antinuclear antibody (ANA), rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP), procalcitonin (PCT), Venereal Disease Research Laboratory test (VDRL), and C-reactive protein (CRP). Results were compared to a control group of 21 individuals who never tested positive for COVID-19. Among severe COVID-19 patients, 26 reacted to ANA, 16 to VDRL, 2 had elevated RF, 12 had increased PCT, and 11 had high CRP, whereas the control group showed no reactive results. Anti-CCP values were not significant. Findings suggest that hyperinflammation may contribute to autoimmunity, particularly in cases of reactive ANA levels, linking COVID-19 symptoms to autoimmune responses. (AU) | |
| Processo FAPESP: | 21/08624-0 - Síndrome pós-COVID: sequelas imunológicas pós infecção por COVID-19 |
| Beneficiário: | Marcel Cerqueira Cesar Machado |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 22/02109-9 - Síndrome pós COVID: sequelas imunologicas pós infecção por COVID 19 |
| Beneficiário: | Raquel Bragante Gritte |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 23/07917-9 - Pesquisa de autoanticorpos em pacientes que tiveram covid-19 de forma leve, moderada e grave. |
| Beneficiário: | Camille Cosme Rodrigues Bianchi |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |