Chemical, spectroscopic characterization, DFT stud... - BV FAPESP
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Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-L-cysteine

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Autor(es):
Abbehausen, Camilla [1] ; Heinrich, Tassiele A. [2] ; Abrao, Emiliana P. [2] ; Costa-Neto, Claudio M. [2] ; Lustri, Wilton R. [3] ; Formiga, Andre L. B. [1] ; Corbi, Pedro P. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas UNICAMP, Inst Quim, BR-13083970 Campinas, SP - Brazil
[2] FMRP USP, Dept Bioquim & Imunol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Ctr Univ Araraquara UNIARA, Assoc Sao Bento Ensino, Dept Ciencias Biol & Saude, BR-14801320 Araraquara, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Polyhedron; v. 30, n. 4, p. 579-583, MAR 11 2011.
Citações Web of Science: 19
Resumo

A new silver(I) complex with N-acetyl-t-cysteine (NAC) of composition AgC(5)H(8)NO(3)S center dot H(2)O was synthesized and characterized by a set of chemical and spectroscopic measurements. Solid-state (13)C nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Ag(I) through the sulfur atom. The Ag-NAC complex is slightly soluble in dimethyl sulfoxide. It is insoluble in water, methanol, ethanol, acetone and hexane. Antibacterial activity of the silver complex with N-acetyl-t-cysteine (Ag-NAC) was evaluated by antibiogram assays using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coil and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for evaluation of a potential cytotoxic effect of Ag-NAC was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a significant cytotoxic activity, inducing 80% of cell death at a concentration of 200 mu mol L(-1). (C) 2010 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 06/55367-2 - Complexos metálicos de platina (II), platina (IV), paládio (II), ouro (I) e ouro (III) com aminoácidos e derivados: síntese, caracterização e aplicações farmacológicas
Beneficiário:Pedro Paulo Corbi
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores