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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Pro-inflammatory effects of the aqueous extract of Echinometra lucunter sea urchin spines

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Autor(es):
Sciani, Juliana Mozer [1, 2] ; Zychar, Bianca Cestari [3] ; Goncalves, Luis Roberto Camargo [3] ; Nogueira, Thiago de Oliveira [3] ; Giorgi, Renata [3] ; Pimenta, Daniel Carvalho [1, 2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Ctr Biol Marinha, BR-11600000 Sao Sebastiao, SP - Brazil
[3] Inst Butantan, Lab Fisiopatol, BR-05503900 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Experimental Biology and Medicine; v. 236, n. 3, p. 277-280, MAR 2011.
Citações Web of Science: 11
Resumo

The sea urchin, Echinometra lucunter, can be found along the Western Central Atlantic shores. In Brazil, it is responsible by circa 50% of the accidents caused by marine animals. The symptoms usually surpass trauma and may be pathologically varied and last differently, ranging from spontaneous healing in a few days, to painful consequences lasting for weeks. In this work, we have mimicked the sea urchin accident by administering an aqueous extract of the spine into mice and rats and evaluated the pathophysiological developments. Our data clearly indicate that the sea urchin accident is indeed a pro-inflammatory event, triggered by toxins present in the spine that can cause edema and alteration in the leukocyte-endothelial interaction. Moreover, the spine extract was shown to exhibit a hyperalgesic effect. The extract is rich in proteins, as observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, but also contains other molecules that can be analyzed by reversed phase high-performance liquid chromatography. Altogether, these effects corroborate that an E. lucunter encounter is an accident and not an incident, as frequently reported by the victims. (AU)

Processo FAPESP: 07/02476-1 - Identificação e caracterização bioquímica de peptídeos e proteínas na secreção cutânea de Chaunus jimi (Bufonidae, Anura, Amphibia)
Beneficiário:Daniel Carvalho Pimenta
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 07/08478-6 - Isolamento e caracterização bioquímica de peptídeos e proteínas de Echinometra lucunter monitorado por efeito biológico.
Beneficiário:Juliana Mozer Sciani
Linha de fomento: Bolsas no Brasil - Doutorado