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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

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Autor(es):
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Valvassori, Samira S. [1, 2] ; Elias, Guilherme [1, 2] ; de Souza, Bruna [1, 2] ; Petronilho, Fabricia [2, 1] ; Dal-Pizzol, Felipe [2, 1] ; Kapczinski, Flavio [1, 3, 4] ; Trzesniak, Clarissa [5, 1] ; Tumas, Vitor [5, 1] ; Dursun, Serdar [1, 6] ; Nisihara Chagas, Marcos Hortes [5, 1] ; Hallak, Jaime E. C. [5, 1] ; Zuardi, Antonio W. [5, 1] ; Quevedo, Joao [2, 1] ; Crippa, Jose A. S. [5, 1]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] CNPq, INCT Translat Med, Campinas, SP - Brazil
[2] Univ Extremo Sul Catarinense, Lab Neurociencias, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, Criciuma, SC - Brazil
[3] Hosp Clin Porto Alegre, Bipolar Disorders Programme, Porto Alegre, RS - Brazil
[4] Hosp Clin Porto Alegre, Lab Mol Psychiat, Ctr Pesquisas, Porto Alegre, RS - Brazil
[5] Univ Sao Paulo, Dept Behav Neurosci, Div Psychiat, Ribeirao Preto Med Sch, BR-14049 Ribeirao Preto, SP - Brazil
[6] Univ Alberta, Dept Psychiat, Edmonton, AB - Canada
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PSYCHOPHARMACOLOGY; v. 25, n. 2, p. 274-279, FEB 2011.
Citações Web of Science: 25
Resumo

Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the D-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against D-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against D-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered. (AU)

Processo FAPESP: 02/13197-2 - Participação do glutamato e óxido nítrico na fisiopatogenia de distúrbios neuropsiquiátricos
Beneficiário:Francisco Silveira Guimaraes
Linha de fomento: Auxílio à Pesquisa - Temático