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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Midazolam reduces the selective activation of the rhinal cortex by contextual fear stimuli

Texto completo
Albrechet-Souza, Lucas [1, 2] ; Borelli, Karina G. [3, 1] ; Almada, Rafael C. [2, 1] ; Brandao, Marcus L. [1, 2]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Inst Neurociencias & Comportamento INeC, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Lab Psicobiol FFCLRP, BR-14040901 Ribeirao Preto, SP - Brazil
[3] Univ Fed ABC, Ctr Matemat Computacao & Cognicao, Nucleo Cognicao & Sistemas Complexos, Santo Andre, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Behavioural Brain Research; v. 216, n. 2, p. 631-638, JAN 20 2011.
Citações Web of Science: 10

Independent brain circuits appear to underlie different forms of conditioned fear, depending on the type of conditioning used, such as a context or explicit cue paired with footshocks. Several clinical reports have associated damage to the medial temporal lobe (MTL) with retrograde amnesia. Although a number of studies have elucidated the neural circuits underlying conditioned fear, the involvement of MTL components in the aversive conditioning paradigm is still unclear. To address this issue, we assessed freezing responses and Fos protein expression in subregions of the rhinal cortex and ventral hippocampus of rats following exposure to a context, light or tone previously paired with footshock (Experiment 1). A comparable degree of freezing was observed in the three types of conditioned fear, but with distinct patterns of Fos distribution. The groups exposed to cued fear conditioning did not show changes in Fos expression, whereas the group subjected to contextual fear conditioning showed selective activation of the ectorhinal (Ect), perirhinal (Per), and entorhinal (Ent) cortices, with no changes in the ventral hippocampus. We then examined the effects of the benzodiazepine midazolam injected bilaterally into these three rhinal subregions in the expression of contextual fear conditioning (Experiment 2). Midazolam administration into the Ect, Per, and Ent reduced freezing responses. These findings suggest that contextual and explicit stimuli endowed with aversive properties through conditioning recruit distinct brain areas, and the rhinal cortex appears to be critical for storing context-, but not explicit cue-footshock, associations. (C) 2010 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 06/06354-5 - Psicobiologia do medo e da ansiedade
Beneficiário:Marcus Lira Brandão
Linha de fomento: Auxílio à Pesquisa - Temático