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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents

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Autor(es):
Oyama, Lila Missae [1, 2] ; Oller do Nascimento, Claudia Maria [1, 3] ; Carnier, June [1] ; de Piano, Aline [1] ; Tock, Lian [1] ; Sanches, Priscila de Lima [1] ; Correa Gomes, Fabiola Alvise [1] ; Tufik, Sergio [4] ; de Mello, Marco Tulio [1, 4] ; Damaso, Ana R. [1, 2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo Unifesp, Post Grad Program Nutr, BR-04020060 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo Unifesp, Dept Biosci, BR-04020060 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo Unifesp, Dept Physiol, BR-04020060 Sao Paulo - Brazil
[4] Univ Fed Sao Paulo Unifesp, Dept Psychobiol, BR-04020060 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Neuropeptides; v. 44, n. 6, p. 467-474, DEC 2010.
Citações Web of Science: 22
Resumo

Obesity is characterized as an inflammatory state associated with a modification in the pattern of adipokine secretion The present study aimed to assess the role of anorexigenic and orexigenic neuropeptides and peripheral signals in obese adolescents submitted to 1 year of weight loss interdisciplinary therapy and grouped according to quartiles of weight loss A total of 111 post-puberty adolescents with a BMI >95th percentile were included Glycemia and lipid profiles were analyzed Insulin resistance was estimated by HOMA-IR. Cytokine concentrations were measured by ELISA. The results are presented according to quartiles of weight loss 1st (<2 5 kg) = low 2nd (2 5-8 kg) = low to moderate 3rd (8-14 kg) = moderate and 4th (>14 kg) = massive The most important finding was that the NPY concentration Increased significantly only in the first phase of weight loss Moreover alpha-MSH variation was an independent factor in explaining the NPY changes during the intervention confirming the role of the alpha-MSH concentration in the peripheral control of energy balance in obese adolescents Indeed BMI reduction was correlated with increased alpha-MSH (p < 0 05) Massive weight loss promoted a significant increase in alpha-MSH concentration and hyperleptinemia was reduced after intervention All together our findings which contribute to our understanding of how orexigenic and anorexigenic systems are regulated by weight loss will provide insight into the pathogenesis and treatment of obesity and other metabolic diseases especially in obese adolescents (C) 2010 Elsevier Ltd All rights reserved (AU)

Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular