Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Texto completo
Autor(es):
Biancardi, Manoel F. [1] ; Santos, Fernanda C. A. [2] ; Madi-Ravazzi, Liliam [3] ; Goes, Rejane M. [3] ; Vilamaior, Patricia S. L. [4] ; Felisbino, Sergio L. [5] ; Taboga, Sebastiao R. [3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Inst Biol, Dept Cell Biol, Campinas, SP - Brazil
[2] Univ Fed Goias, Dept Morphol, Goiania, Go - Brazil
[3] Sao Paulo State Univ, UNESP IBILCE, Dept Biol, Lab Microscopy & Microanal, Sao Paulo - Brazil
[4] UNIRP, Rio Preto Universitary Ctr, Biol Sci & Vet Med Sch, Sao Paulo - Brazil
[5] Sao Paulo State Univ, UNESP IB, Inst Biol, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology; v. 293, n. 12, p. 2163-2175, DEC 2010.
Citações Web of Science: 7
Resumo

The female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. On the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults. Anat Rec, 293:2163-2175, 2010. (C) 2010 Wiley-Liss, Inc. (AU)

Processo FAPESP: 07/06862-3 - Desenvolvimento da próstata masculina e feminina do gerbilo da Mongólia sob efeito da exposição intra-uterina e pós-natal de testosterona
Beneficiário:Manoel Francisco Biancardi
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 06/06876-1 - Aspectos morfofuncionais da próstata feminina do gerbilo durante o ciclo estral
Beneficiário:Sebastião Roberto Taboga
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 05/04647-2 - Influência da testosterona sobre a morfofisiologia da próstata feminina de ratas Wistar adultas
Beneficiário:Manoel Francisco Biancardi
Linha de fomento: Bolsas no Brasil - Iniciação Científica