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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Traditional biomarkers in narcolepsy Experience of a brazilian sleep centre

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Autor(es):
Santos Coelho, Fernando Morgadinho [1, 2] ; Pradella-Hallinan, Marcia [1] ; Pedrazzoli, Mario [1] ; Senne Soares, Carlos Augusto [2] ; Peres Fernandes, Gustavo Bruniera [2] ; Goncalves, Andre Leite [2] ; Tufik, Sergio [1] ; Azeredo Bittencourt, Lia Rita [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Israelita Albert Einstein Hosp, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Arquivos de Neuro-Psiquiatria; v. 68, n. 5, p. 712-715, OCT 2010.
Citações Web of Science: 8
Resumo

This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at Sao Paulo, Brazil. Method: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1(star)0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level: Normal (N) - Hypocretin-1 higher than 110pg/m1 and Lower (L) Hypocretin-1 lower than 110 pg/ml. Results: Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p=0.0002). Discussion: This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1(star)0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1(star)0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs