Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Osteoconductivity of modified fluorcanasite glass-ceramics for bone tissue augmentation and repair

Texto completo
Autor(es):
Bandyopadhyay-Ghosh, S. [1, 2] ; Faria, P. E. P. [3] ; Johnson, A. [2] ; Felipucci, D. N. B. [4] ; Reaney, I. M. [1] ; Salata, L. A. [5] ; Brook, I. M. [2] ; Hatton, P. V. [2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sheffield, Dept Mat Engn, Sheffield S1 3JD, S Yorkshire - England
[2] Univ Sheffield, Ctr Biomat & Tissue Engn, Sch Clin Dent, Sheffield S10 2TA, S Yorkshire - England
[3] Univ State Sao Paulo, Dept Oral & Maxillofacial Surg, Fac Dent Aracatuba, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Prosthodont, Fac Dent Ribeirao Preto, Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Oral & Maxillofacial Surg, Fac Dent Ribeirao Preto, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Journal of Biomedical Materials Research Part A; v. 94A, n. 3, p. 760-768, SEP 1 2010.
Citações Web of Science: 11
Resumo

Modified fluorcanasite glasses were fabricated by either altering the molar ratios of Na(2)O and CaO or by adding P(2)O(5) to the parent stoichiometric glass compositions. Glasses were converted to glass-ceramics by a controlled two-stage heat treatment process. Rods (2 mm x 4 mm) were produced using the conventional lost-wax casting technique. Osteoconductive 45S5 bioglass was used as a reference material. Biocompatibility and osteoconductivity were investigated by implantation into healing defects (2 mm) in the midshaft of rabbit femora. Tissue response was investigated using conventional histology and scanning electron microscopy. Histological and histomorphometric evaluation of specimens after 12 weeks implantation showed significantly more bone contact with the surface of 45S5 bioglass implants when compared with other test materials. When the bone contact for each material was compared between experimental time points, the Glass-Ceramic 2 (CaO rich) group showed significant difference (p = 0.027) at 4 weeks, but no direct contact at 12 weeks. Histology and backscattered electron photomicrographs showed that modified fluorcanasite glass-ceramic implants had greater osteoconductivity than the parent stoichiometric composition. Of the new materials, fluorcanasite glass-ceramic implants modified by the addition of P(2)O(5) showed the greatest stimulation of new mineralized bone tissue formation adjacent to the implants after 4 and 12 weeks implantation. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 94A: 760-768, 2010 (AU)

Processo FAPESP: 05/58132-3 - Estudo in vivo da biocompatibilidade de cerâmicas de vidro fluoretadas (fluorcanasites) com diferentes composições como material de substituição de tecido ósseo
Beneficiário:Daniela Nair Borges Felipucci
Linha de fomento: Bolsas no Brasil - Iniciação Científica