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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Balanced polymorphism in bottlenecked populations: The case of the CCR5 5 ` cis-regulatory region in Amazonian Amerindians

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Autor(es):
Ramalho, Rodrigo F. [1] ; Santos, Eduardo J. M. [2] ; Guerreiro, Joao F. [2] ; Meyer, Diogo [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, Sao Paulo - Brazil
[2] Fed Univ Para, Ctr Ciencias Biol, Lab Genet Humana & Med, BR-66059 Belem, PA - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: HUMAN IMMUNOLOGY; v. 71, n. 9, p. 922-928, SEP 2010.
Citações Web of Science: 6
Resumo

The 5' cis-regulatory region of the CCR5 gene exhibits a strong signature of balancing selection in several human populations. Here we analyze the polymorphism of this region in Amerindians from Amazonia, who have a complex demographic history, including recent bottlenecks that are known to reduce genetic variability. Amerindians show high nucleotide diversity (pi = 0.27%) and significantly positive Tajima's D, and carry haplotypes associated with weak and strong gene expression. To evaluate whether these signatures of balancing selection could be explained by demography, we perform neutrality tests based on empiric and simulated data. The observed Tajima's D was higher than that of other world populations: higher than that found for 18 noncoding regions of South Amerindians, and higher than 99.6% of simulated genealogies, which assume nonequilibrium conditions. Moreover, comparing Amerindians and Asians, the Fst for CCR5 cis-regulatory region was unusually low, in relation to neutral markers. These findings indicate that, despite their complex demographic history, South Amerindians carry a detectable signature of selection on the CCR5 cis-regulatory region. (C) 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 04/11521-2 - Estudo dos efeitos da seleção natural sobre a região controladora do gene CCR5 em populações indígenas brasileiras
Beneficiário:Rodrigo Fernandes Ramalho
Linha de fomento: Bolsas no Brasil - Mestrado