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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Development and Application of a Highly Selective Biomimetic Sensor for Detection of Captopril, an Important Ally in Hypertension Control

Texto completo
Autor(es):
Wong, Ademar [1] ; Lanza, Marcos R. V. [2] ; Sotomayor, Maria D. P. T. [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Dept Quim Analit IQ, BR-14801970 Araraquara, SP - Brazil
[2] Univ Sao Paulo, Dept Quim & Fis Mol IQSC, BR-13560970 Sao Carlos, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING; v. 13, n. 8, 3, p. 666-674, SEP 2010.
Citações Web of Science: 10
Resumo

A biomimetic sensor is proposed as a promising new analytical method for determination of captopril in different classes of samples. The sensor was prepared by modifying a carbon paste electrode with iron (II) phthalocyanine bis(pyridine) {[}FePe(dipy)] complex. Amperometric measurements in a batch analytical mode were first carried out in order to optimize the sensor response. An applied potential lower than 0.2 V vs Ag vertical bar AgCl in 0.1 mol L(-1) of TRIS buffer at pH 8.0 provided the best response, with a linear range of 2.5 x 10(-5) to 1.7 x 10(-4) mol L(-1). A detailed investigation of the selectivity of the sensor, employing seventeen other drugs, was also performed. Recovery studies were carried out using biological and environment samples in order to evaluate the sensor's potential for use with these sample classes. Finally, the performance of the biomimetic sensor was optimized in a flow injection (FIA) system using a wall jet electrochemical cell. Under optimized flow conditions, a broad linear response range, from 5.0 x 10(-4) to 2.5 x 10(-2) mol L(-1), was obtained for captopril, with a sensitivity of 210 +/- 1 mu A L mol(-1). (AU)

Processo FAPESP: 08/08035-0 - Construção de sensores biomiméticos para determinação de resíduos farmacêuticos em águas de plantas de tratamento de esgoto e de rios no Estado de São Paulo
Beneficiário:Ademar Wong
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 08/00303-5 - Construção de sensores biomiméticos para determinação de fármacos e seu acoplamento a sistemas em fluxo
Beneficiário:Maria Del Pilar Taboada Sotomayor
Linha de fomento: Auxílio à Pesquisa - Regular