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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

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Autor(es):
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Gaudet, Mia M. [1, 2] ; Olshan, Andrew F. [3] ; Chuang, Shu-Chun [4, 5] ; Berthiller, Julien [6] ; Zhang, Zuo-Feng [7] ; Lissowska, Jolanta [8, 9] ; Zaridze, David [10] ; Winn, Deborah M. [11] ; Wei, Qingyi [12] ; Talamini, Renato [13] ; Szeszenia-Dabrowska, Neolilia [14] ; Sturgis, Erich M. [11] ; Schwartz, Stephen M. [15] ; Rudnai, Peter [16] ; Eluf-Neto, Jose [17] ; Muscat, Joshua [18] ; Morgenstern, Hal [19, 20] ; Menezes, Ana [21] ; Matos, Elena [22] ; Bucur, Alexandru [23] ; Levi, Fabio [24] ; Lazarus, Philip [18] ; La Vecchia, Carlo [25] ; Koifman, Sergio [26] ; Kelsey, Karl [27] ; Herrero, Rolando [28] ; Hayes, Richard B. [11] ; Franceschi, Silva [4] ; Wunsch-Filho, Victor [21] ; Fernandez, Leticia [29] ; Fabianova, Eleonora [30] ; Daudt, Alexander W. [31] ; Dal Maso, Luigino [13] ; Curado, Maria Paula [4, 32] ; Chen, Chu [15] ; Castellsague, Xavier [33] ; Benhamou, Simone [34, 35] ; Boffetta, Paolo [4] ; Brennan, Paul [4] ; Hashibe, Mia [36]
Número total de Autores: 40
Afiliação do(s) autor(es):
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[1] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 - USA
[2] Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10467 - USA
[3] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC - USA
[4] Int Agcy Res Canc, F-69372 Lyon - France
[5] Univ London Imperial Coll Sci Technol & Med, London - England
[6] Hosp Civils Lyon, Lyon - France
[7] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA
[8] Maria Sklodowska Curie Mem Canc Ctr, Warsaw - Poland
[9] Inst Oncol, Warsaw - Poland
[10] Russian Acad Med Sci, Canc Res Ctr, Moscow - Russia
[11] NCI, Bethesda, MD 20892 - USA
[12] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 - USA
[13] Aviano Canc Ctr, I-33081 Aviano - Italy
[14] Inst Occupat Med, Lodz - Poland
[15] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 - USA
[16] Natl Inst Environm Hlth, Budapest - Hungary
[17] Univ Sao Paulo, Sao Paulo - Brazil
[18] Penn State Coll Med, Hershey, PA - USA
[19] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI - USA
[20] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI - USA
[21] Univ Fed Pelotas, Pelotas - Brazil
[22] Univ Buenos Aires, Inst Oncol Angel H Roffo, RA-1053 Buenos Aires, DF - Argentina
[23] Univ Med & Pharm Carol Davila, Bucharest - Romania
[24] Inst Univ Med Sociale & Prevent, CH-1005 Lausanne - Switzerland
[25] Ist Ric Farmacol Mario Negri, Milan - Italy
[26] Escola Nacl Saude Publica, Rio De Janeiro - Brazil
[27] Brown Univ, Bio Med Ctr Environm & Technol, Providence, RI 02912 - USA
[28] Inst Invest Epidemiol, San Jose - Costa Rica
[29] Inst Oncol & Radiobiol, Havana - Cuba
[30] Specialized State Hlth Inst, Banska Bystrica - Slovakia
[31] Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil
[32] Hosp Araujo Jorge, Goiania, Go - Brazil
[33] CIBER ESP, IDIBELL, Inst Catala Oncol, Lhospitalet De Llobregat - Spain
[34] INSERM, U794, Paris - France
[35] CNRS, FRE2939, Villejuif - France
[36] Univ Utah, Sch Med, Dept Family & Prevent Med, Salt Lake City, UT 84108 - USA
Número total de Afiliações: 36
Tipo de documento: Artigo Científico
Fonte: International Journal of Epidemiology; v. 39, n. 4, p. 1091-1102, AUG 2010.
Citações Web of Science: 52
Resumo

Methods We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) < 18.5 kg/m(2) (2.13, 1.75-2.58) and reduced for BMI > 25.0-30.0 kg/m(2) (0.52, 0.44-0.60) and BMI >= 30 kg/m(2) (0.43, 0.33-0.57), compared with BMI > 18.5-25.0 kg/m(2). These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI < 18.5 kg/m(2) was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m(2) was present only in smokers and drinkers. Conclusions In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies. (AU)

Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
Beneficiário:José Eluf Neto
Linha de fomento: Auxílio à Pesquisa - Regular