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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The role of nutritional profile in the orexigenic neuropeptide secretion in nonalcoholic fatty liver disease obese adolescents

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Autor(es):
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de Piano, Aline [1] ; Tock, Lian [1] ; Carnier, June [1] ; Foschini, Denis [1] ; Sanches, Priscila de Lima [1] ; Correa, Fabiola Alvise [1] ; Oyama, Lila Missae [1] ; Oller do Nascimento, Claudia Maria [1] ; Lederman, Henrique Manoel [2] ; Ernandes, Regina [3] ; de Mello, Marco Tulio [4] ; Tufik, Sergio [4] ; Damaso, Ana [5, 1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Fed Univ Sao Paulo Unifesp, Post Grad Program Nutr, Sao Paulo - Brazil
[2] Fed Univ Sao Paulo Unifesp, Dept Diagnost Imaging, Sao Paulo - Brazil
[3] Fed Univ Sao Paulo Unifesp, Associat Found Incent Physicobiol, Sao Paulo - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo - Brazil
[5] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY; v. 22, n. 5, p. 557-563, MAY 2010.
Citações Web of Science: 15
Resumo

Background Little progress has been made to identify the central neuroendocrine pathway involved in the energy intake control in nonalcoholic fatty liver disease (NAFLD) patients. Objective To assess the influence of orexigenic neuropeptides in the nutritional aspects of NAFLD obese adolescents submitted to a long-term interdisciplinary approach. Methods Fifty adolescents aged 15-19 years, with body mass index at least 95th percentile, consisting of 25 patients without NAFLD and 25 with NAFLD. The NAFLD diagnosis was determined by ultrasonography. Blood samples were collected to analyze glycemia, hepatic transaminases, and lipid profile. Insulin resistance was estimated by Homeostasis Model Assessment Insulin Resistance Index. Neuropeptide Y (NPY) and agouti related protein concentrations were measured by enzyme-linked immunosorbent assay. Analyses of food intake were made by 3 days recordatory inquiry. Results At baseline conditions, the patients with NAFLD had significantly higher values of body mass, body mass index, visceral fat, triglycerides, VLDL-C, and hepatic transaminases. After the long-term intervention, they presented a significant reduction in these parameters. In both the groups, it was observed a significant decrease in energy intake, macronutrients and dietetic cholesterol. Only the patients with NAFLD presented a positive correlation between the saturated fatty acids intake and the orexigenic neuropeptides NPY and agouti related protein, and carbohydrate with NPY. Indeed, it was observed a positive correlation between energy intake, lipid (%) and saturated fatty acids with visceral fat accumulation. Conclusion Our findings showed an important influence of diet composition in the orexigenic system, being essential consider that the excessive saturated fatty acids intake could be a determinant factor to increase nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol 22:557-563 (C) 2010 Wolters Kluwer Health | Lippincott Williams \& Wilkins. (AU)

Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular