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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Relationship between environmental factors and gray matter atrophy in refractory MTLE

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Autor(es):
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Yasuda, C. L. [1, 2] ; Morita, M. E. [1, 2] ; Alessio, A. [1, 2] ; Pereira, A. R. [3] ; Balthazar, M. L. F. [1, 2] ; Saude, A. V. [4] ; Costa, A. L. F. [2] ; Costa, A. L. C. [1] ; Cardoso, T. A. [1] ; Betting, L. E. [1, 2] ; Guerreiro, C. A. M. [1] ; Damasceno, B. P. [1] ; Lopes-Cendes, I. [5, 4] ; Tedeschi, H. [1] ; de Oliveira, E. [1] ; Cendes, F. [1, 2]
Número total de Autores: 16
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Neurol, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Lab Neuroimaging, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, BR-13083970 Campinas, SP - Brazil
[4] Univ Fed Lavras, Dept Comp Sci, Lavras - Brazil
[5] Univ Estadual Campinas, Dept Med Genet, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Neurology; v. 74, n. 13, p. 1062-1068, MAR 30 2010.
Citações Web of Science: 14
Resumo

Objective: To investigate clinical, neuropsychological, and MRI abnormalities (gray matter atrophy {[}GMA] and white matter atrophy {[}WMA]) in surgical mesial temporal lobe epilepsy (MTLE) patients with and without familial antecedent for epilepsy. Methods: A cohort study including 69 operated patients with unilateral MTLE, divided into a group of 29 patients (mean age 35.8 +/- 10.4 years) with a negative family history (FH) of epilepsy and a group of 40 patients (32.8 +/- 10 years) with a positive FH. We performed voxel-based morphometry (VBM) on preoperative MRIs and investigated possible clinical and neuropsychological differences between the 2 groups. We also performed VBM and t tests to compare the patients' groups with normal controls. Results: The negative-FH group had lower IQ scores (p = 0.004), performed poorer on the Boston Naming Test (p = 0.02) and on delayed recall (p = 0.03), and presented a more prominent asymmetry index of hippocampal volume (p = 0.04) and more frequent initial precipitating injuries (p = 0.023). VBM showed a more restricted pattern of GMA in the positive-FH group and a more bilateral and widespread pattern of GMA in the negative-FH group, involving thalami, temporal, frontal, parietal, and occipital lobes. WMA was widespread and bilateral in both groups. Conclusions: The more widespread structural voxel-based morphometry abnormalities and worse IQ performance identified in the negative-family history (FH) group may result from a stronger environmental influence, including initial precipitating injuries. This is further support for the hypothesis that hippocampal sclerosis in mesial temporal lobe epilepsy with positive FH is determined by a stronger genetic predisposition with less influence of environmental factors compared with patients in the negative-FH group. Neurology(R) 2010;74:1062-1068 (AU)

Processo FAPESP: 05/59258-0 - Comparação prospectiva entre os tratamentos clínico e cirúrgico para epilepsia de lobo temporal medial
Beneficiário:Clarissa Lin Yasuda
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 06/59101-7 - Epilepsia de lobo temporal familial: caracterização da evolução natural, progressão da atrofia hipocampal e resposta ao tratamento
Beneficiário:Marcia Elisabete Morita
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 07/55187-7 - Análise de fatores prognósticos da cirurgia para epilepsia do lobo temporal mesial
Beneficiário:Amanda Régio Pereira
Linha de fomento: Bolsas no Brasil - Iniciação Científica