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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

L-Allylglycine dissociates the neural substrates of fear in the periaqueductal gray of rats

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Autor(es):
Cunha, Joice Maria [1, 2] ; Zanoveli, Janaina Menezes [2, 1] ; Ledvinka-Filho, Eduardo [1, 2] ; Brandao, Marcus Lira [2, 1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Lab Psicobiol, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14090901 Ribeirao Preto, SP - Brazil
[2] INeC, BR-14040901 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Brain Research Bulletin; v. 81, n. 4-5, p. 416-423, MAR 16 2010.
Citações Web of Science: 6
Resumo

The dorsal (dPAG) and ventral (vPAG) regions of the periaqueductal gray are well known to contain the neural substrates of fear and anxiety. Chemical or electrical stimulation of the dPAG induces freezing, followed by a robust behavioral reaction that has been considered an animal model of panic attack. In contrast, the vPAG is part of a neural system, in which immobility is the usual response to its stimulation. The defense reaction induced by the stimulation of either region is accompanied by anti nociception. Although GABAergic mechanisms are known to exert tonic inhibitory control on the neural substrates of fear in the dPAG, the role of these mechanisms in the vPAG is still unclear. The present study examined defensive behaviors and antinociception induced by microinjections of an inhibitor of gamma-aminobutyric acid synthesis, L-allylglycine (L-AG; 1, 3, and 5 mu g/0.2 mu l), into either the dPAG or vPAG of rats subjected to the open field and tail-flick tests. Passive or tense immobility was the predominant behavior after L-AG (1 or 3 mu g) microinjection into the vPAG and dPAG, respectively, which was replaced with intense hyperactivity, including jumps or rearings, after injections of a higher dose (5 mu g/0.2 mu l) into the dPAG or vPAG. Moreover, whereas intra-dPAG injection of 3 mu g L-AG produced intense antinociception, only weak antinociception was induced by intra-vPAG injections of 5 mu g L-AG. These findings suggest that GABA mechanisms are involved in the mediation of antinociception and behavioral inhibition to aversive stimulation of the vPAG and exert powerful control over the neural substrates of fear in the dPAG to prevent a full-blown defense reaction possibly associated with panic disorder. (C) 2009 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 06/06354-5 - Psicobiologia do medo e da ansiedade
Beneficiário:Marcus Lira Brandão
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 06/54387-0 - Participação do núcleo basolateral da amígdala na mediação de respostas condicionadas e incondicionadas de medo geradas pela estimulação química da substância cinzenta periaquedutal dorsal
Beneficiário:Janaina Menezes Zanoveli
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 08/54445-5 - Envolvimento do sistema serotonérgico e dos receptores opióides, benzodiazepínicos e canabinóides do tipo CB1 da substância cinzenta periaquedutal nas respostas condicionadas e incondicionadas de medo
Beneficiário:Joice Maria da Cunha
Linha de fomento: Bolsas no Brasil - Pós-Doutorado