Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Dynamic changes in white and gray matter volume are associated with outcome of surgical treatment in temporal lobe epilepsy

Texto completo
Autor(es):
Mostrar menos -
Yasuda, Clarissa Lin [1, 2] ; Valise, Clarissa [3] ; Saude, Andre Vital [4] ; Pereira, Amanda Regio [2] ; Pereira, Fabricio Ramos [2] ; Ferreira Costa, Andre Luiz [2] ; Morita, Marcia Elisabete [1, 2] ; Betting, Luiz Eduardo [1, 2] ; Castellano, Gabriela [3] ; Mantovani Guerreiro, Carlos Alberto [1] ; Tedeschi, Heider [1] ; de Oliveira, Evandro [1] ; Cendes, Fernando [1, 2]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Neurol, FCM, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Neuroimaging Lab, FCM, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Inst Phys, Gleb Wataghin IFGW, BR-13083970 Campinas, SP - Brazil
[4] Univ Fed Lavras, Lavras, MG - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: NeuroImage; v. 49, n. 1, p. 71-79, JAN 1 2010.
Citações Web of Science: 36
Resumo

Background: The reasons for surgical failure in 30% of patients with unilateral mesial temporal lobe epilepsy (MTLE) are still unclear. We investigated if different outcomes could be associated to different patterns of subtle gray matter atrophy (GMA) and white matter atrophy (WMA), and searched for postoperative magnetic resonance imaging (MRI) changes. Methods: We studied 69 controls and 67 operated patients with refractory unilateral MTLE. Patients were grouped as seizure-free (SF) group (34 patients Engel's IA), worthwhile improvement group (23 patients, Engel's IB-IIA) and failure group (10 patients Engel's IIB-IV). We created a voxel-based morphometry/MATLAB code to mask the surgical lacuna, and performed t-test and paired t-test to evaluate preoperative and postoperative MRI scans. Results: Failure group showed a widespread pattern of preoperative GMA. On SF and improvement groups we identified a more restricted pattern of GMA. The three groups presented a widespread, bilateral pattern of WMA. In contrast, postoperative analyses showed bilateral hemispheric recovery (a relative increase of WM concentration) on SF and improvement groups, but few changes on failure group. We also identified areas with relative postoperative increase of GM on both SF and improvement groups, more widespread on SF group. Conclusion: Areas of subtle GMA may be related to poorer surgical outcome. In addition, we demonstrated a postoperative relative increase of WM and GM concentration associated with seizure control. These changes may represent neuroplasticity related to improvement of brain function after seizure control. Further studies with a multimodal approach may help to predict surgical outcome and improve selection of patients for surgical treatment of MTLE. (c) 2009 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 05/59258-0 - Comparação prospectiva entre os tratamentos clínico e cirúrgico para epilepsia de lobo temporal medial
Beneficiário:Clarissa Lin Yasuda
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 07/01676-7 - Estudo da aplicação de máscaras na técnica de VBM em MRI de pacientes com ELTM operados
Beneficiário:Clarissa de Castro Valise Fedato
Linha de fomento: Bolsas no Brasil - Iniciação Científica