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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes

Texto completo
Autor(es):
Bannwart, C. F. [1] ; Peracoli, J. C. [2] ; Nakaira-Takahagi, E. [1] ; Peracoli, M. T. S. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Dept Microbiol & Immunol, Biosci Inst, UNESP, BR-18618000 Botucatu, SP - Brazil
[2] Sao Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, BR-18618000 Botucatu, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: NATURAL PRODUCT RESEARCH; v. 24, n. 18, p. 1747-1757, 2010.
Citações Web of Science: 13
Resumo

Silibinin is a chemically defined flavonoid and the main active component of silymarin, a polyphenolic complex from Silybum marianum, which has anti-inflammatory, hepatoprotective and anticarcinogenic properties. Monocytes obtained from healthy individuals were incubated with silibinin to evaluate cell viability, hydrogen peroxide (H2O2) release and tumour necrosis factor-alpha (TNF-) production by these cells. The duration of treatment and different silibinin concentrations had no significant effect on cell viability. Monocytes showed a dose-dependent inhibitory effect on H2O2 release by phorbol myristate acetate-stimulated monocytes in silibinin concentrations ranging from 6.25 to 50 mu g mL-1. Significant inhibition of TNF- production by lipopolysaccharide-stimulated monocytes was observed at concentrations of 12.5, 50 and 100 mu g mL-1 of silibinin. These results suggest that silibinin exerts antioxidant and anti-inflammatory properties on human monocytes through an inhibitory effect on H2O2 release and on TNF- production, respectively. (AU)

Processo FAPESP: 03/10476-0 - Efeito da silimarina (Silybum marianum) sobre a produção de fator de necrose tumoral alfa e peróxido de hidrogênio por monócitos de sangue periférico de indivíduos saudáveis
Beneficiário:Camila Ferreira Bannwart Castro
Linha de fomento: Bolsas no Brasil - Iniciação Científica