Prenatal Lipopolysaccharide Reduces Social Behavior in Male Offspring

Autor(es)

Kirsten, Thiago B. ^[1] ; Taricano, Marina ^[1] ; Maiorka, Paulo C. ^[1] ; Palermo-Neto, Joao ^[1] ; Bernardi, Maria M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Sch Vet Med, Neuroimmunomodulat Res Grp, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NEUROIMMUNOMODULATION; v. 17, n. 4, p. 240-251, 2010.
• Citações Web of Science: 55

Resumo

Objective: This study investigated the relationship between maternal sickness behavior during pregnancy and offspring development and behavior. Methods: Pregnant Wistar rats were administered with lipopolysaccharide (LPS, 100 mu g/kg, i.p.) on gestation day (GD) 9.5. Dams' sickness behavior was analyzed, and at birth, offspring number and weight were evaluated. Male offspring was evaluated through physical development, play behavior, adult social interaction, plus maze studies and morphological analysis of the brain. Results: Results, with respect to the control group, showed that: (1) LPS decreased general activity, food intake, and weight gain in dams, but no pyrexia was observed following treatment; (2) LPS reduced litter size, but no alterations in physical development were observed; (3) LPS reduced play behavior parameters in baby rats; (4) LPS decreased adult social interaction; (5) no alterations were observed between groups on plus maze studies; (6) no differences were observed between groups on morphological analyses of the brain. Conclusion: These data reveal that LPS administered on GD 9.5 impaired male offspring's social behavior in infancy and adulthood. These results may be related to an alteration in motivational states or/and increased anxiety. Copyright (C) 2010 S. Karger AG, Basel (AU)

• Processo FAPESP: 06/54587-9 - Efeitos da administração pré-natal de LPS nos sistemas dopaminérgico e serotoninérgico centrais da prole masculina de ratos
• Beneficiário: Thiago Berti Kirsten
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 04/14128-0 - Neuroimunomodulação: efeitos do estresse e de citocinas nas relações bidirecionais entre os sistemas nervosos central e imune
• Beneficiário: João Palermo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático