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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Non-NMDA receptors in the lateral parabrachial nucleus modulate sodium appetite

Texto completo
Autor(es):
De Gobbi, Juliana I. F. [1] ; Beltz, Terry G. [1] ; Johnson, Ralph F. [1] ; Menani, Jose Vanderlei [1] ; Thunhorst, Robert L. [1] ; Johnson, Alan Kim [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Iowa, Ctr Cardiovasc, Iowa City, IA 52242 - USA
[2] Univ Iowa, Dept Psychol, Iowa City, IA 52242 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Brain Research; v. 1301, p. 44-51, NOV 16 2009.
Citações Web of Science: 23
Resumo

Glutamatergic mechanisms have been implicated in the control of fluid ingestion. In the present study, we investigated whether non-N-methyl-D-aspartate (NMDA) glutamatergic receptors in the lateral parabrachial nucleus (LPBN) are involved in the control of water and sodium intake. Male Sprague-Dawley rats had cannulas implanted bilaterally into the LPBN. They were acutely depleted of water and sodium by injections of the diuretic furosemide (Furo; 10 mg/kg, bw) and given a low dose of the angiotensin-converting enzyme inhibitor, captopril (Cap; 5 mgfkg, bw). Bilateral LPBN injections of the non-NMDA receptor antagonist DNQX (2 and 5 nmol/0.2 mu l) increased the ingestion of 0.3 M NaCl and water of Furo/Cap treated rats. The increased ingestion produced by DNQX was abolished by pretreating the LPBN with alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), a non-NMDA receptor agonist. AMPA injected alone into the LPBN reduced water and 0.3 M NaCl intake. Injections of DNQX (5 nmol/0.2 mu l) into the LPBN also produced ingestion of 0.3 M NaCl after sc injections of the beta-adrenoceptor agonist, isoproterenol, a hypotensive drug that typically produces only water intake. Food intake, arterial blood pressure and heart rate were not altered by DNQX LPBN injections. We conclude that agonists acting on non-NMDA receptors in the LPBN exert an inhibitory influence on sodium intake during acute fluid depletion with hypotension and after isoproterenol. treatment. A possible interaction of serotonin with glutamate within the LPBN is discussed. (C) 2009 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 07/53963-0 - Participação glutamatérgica no núcleo parabraquial na regulação osmótica
Beneficiário:Juliana Irani Fratucci de Gobbi
Linha de fomento: Auxílio à Pesquisa - Regular