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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Imbalance of Tumor Suppression Genes Expression Following Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide

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Autor(es):
Ribeiro, Daniel Araki [1, 2] ; Cuzzuol Fracalossi, Ana Carolina [1] ; Uatari, Silvia Akemi [2] ; Fujiyama Oshima, Celina Tizuko [1] ; Favero Salvadori, Daisy Maria [3]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, UNIFESP, Dept Pathol, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Dept Pathol, Botucatu Med Sch, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: IN VIVO; v. 23, n. 6, p. 937-942, NOV-DEC 2009.
Citações Web of Science: 4
Resumo

This study was undertaken to investigate, by immunohistochemistry, the expression of some tumor suppressor genes such asp 16, p21 and Retinoblastoma (Rb) during 4-Nitroquinoline I-oxide induced rat tongue carcinogenesis. Male Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution through their drinking water for 4, 12 or 20 weeks. Ten animals were used as negative control. Neither histopathological abnormalities were induced in the epithelium after 4 weeks of carcinogen exposure, not-statistically significant differences (p>0.05) in expression of all the tumor suppressor genes were found when compared to the negative control. However, the levels of Rb were increased (p<0.05) in pre-neoplastic lesions at 12 weeks following carcinogen exposure. In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, p16 and Rb were expressed in some tumor cells. Taken together, the results support the belief that the expression of Rb is closely event-related to malignant transformation and conversion of the oral mucosa, being a reliable biomarker linked to oral cancer pathogenesis. (AU)

Processo FAPESP: 07/08210-3 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
Beneficiário:Ana Carolina Cuzzuol Fracalossi
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 07/01228-4 - Carcinogênese bucal quimicamente induzida pela 4-nitroquinolina 1-óxido em ratos: possíveis biomarcadores envolvidos em sua patogênese
Beneficiário:Daniel Araki Ribeiro
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores