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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy

Texto completo
Autor(es):
Luongo, Roberta [1] ; Oliveira, Diana Amaral [1] ; Lebrun, Ivo [2] ; Lopes Sandoval, Maria Regina [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Butantan Inst, Pharmacol Lab, BR-05503900 Sao Paulo - Brazil
[2] Butantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Brain Research Bulletin; v. 79, n. 5, p. 296-302, JUN 30 2009.
Citações Web of Science: 1
Resumo

We have characterized earlier the long-term behavioural, electroencephalographic and histopatologic features after a single TsTx microinjection, consisting of a neuropeptide isolated from the Tityus serrulatus scorpion venom, into the hippocampus of rats. TsTx was able to induce status epilepticus (SE) and developed later epilepsy. The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6 h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs). mossy fibre sprouting and hippocampal neurodegeneration in rats. The administration of diazepam (DZ) + pentobarbital (PB) 30 min after the beginning of the TsTx-induced SE was able to markedly reduce the frequency of the SRMSs and prevent the development of mossy fibres sprouting and hippocampal lesion. In the other groups the augment of the extent of hipocampal neurodegeneration, the frequency of SRMSs and degree of aberrant mossy fibre sprouting was directly proportional to the time that the animals were subjected to TsTx-induced SE. In conclusion, our results point out that the early blockade of the TsTx-induced SE with diazepam plus pentobarbital, was effective treatment against later epilepsy development. The effectiveness of this treatment depends on the time that the animals were subjected to the SE. Furthermore, the TsTx model could be a useful tool to study antiepileptogenic drugs in chronic epileptic animals, neuronal degeneration, as well as for the mechanisms underlying epilepsy. (C) 2009 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 04/01817-1 - Estudos de toxinas isoladas de venenos animais com atividade neurotoxica no sistema nervoso central.
Beneficiário:Maria Regina Lopes Sandoval
Linha de fomento: Auxílio à Pesquisa - Regular