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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Autoimmune diseases in the TH17 era

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Autor(es):
Mesquita, Jr., D. [1] ; Cruvinel, W. M. [2, 1] ; Camara, N. O. S. [3] ; Kallas, E. G. [4] ; Andrade, L. E. C. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Escola Paulista Med, Div Reumatol, BR-04023069 Sao Paulo - Brazil
[2] Univ Catolica Goias, Dept Biomed, Goiania, Go - Brazil
[3] Univ Sao Paulo, Fac Med, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Med, Dept Clin Med, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: Brazilian Journal of Medical and Biological Research; v. 42, n. 6, p. 476-486, JUN 2009.
Citações Web of Science: 20
Resumo

A new subtype of CD4(+) T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases, the fine balance between the proportion and degree of activation of the various T lymphocyte subsets can contribute to persistent undesirable inflammatory responses and tissue replacement by fibrosis. This review highlights the importance of TH17 cells in this process by providing an update on the biology of these cells and focusing on their biology and differentiation processes in the context of immune-mediated chronic inflammatory diseases. (AU)

Processo FAPESP: 07/07139-3 - Investigando o papel da heme-oxigenase 1 em diferentes processos inflamatórios renais em modelos animais
Beneficiário:Niels Olsen Saraiva Câmara
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 07/51349-2 - Avaliação fenotípica das células T regulatórias CD4+CD25+ em pacientes com lúpus erimatoso sistêmico
Beneficiário:Luiz Eduardo Coelho Andrade
Linha de fomento: Auxílio à Pesquisa - Regular