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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of dopamine receptors in the ventral tegmental area in conditioned fear

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Autor(es):
de Oliveira, Amanda Ribeiro [1, 2] ; Reimer, Adriano Edgar [1, 2] ; Brandao, Marcus Lira [1, 2]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] INeC, Ribeirao Preto, SP - Brazil
[2] USP, FFCLRP, Lab Psicobiol, Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Behavioural Brain Research; v. 199, n. 2, p. 271-277, MAY 16 2009.
Citações Web of Science: 40
Resumo

The increased startle reflex in the presence of a stimulus that has been previously paired with foot-shock has been termed fear-potentiated startle (FPS) and is considered a reliable index of anxiety. Some studies have suggested an association between stressful situations and alterations in dopaminergic (DA) transmission. Many studies converge on the hypothesis that the mesocorticolimbic pathway, originating from DA neurons in the ventral tegmental area (VTA), is particularly sensitive to fear-arousing stimuli. The present study explored the involvement of VTA DA receptors in the acquisition and expression of conditioned fear to a light conditioned stimulus (CS), We evaluated the effects of intra-VTA administration of SKF 38393 (D(1) agonist), SCH 23390 (D(1) antagonist), quinpirole (D(2) agonist), and sulpiride (D2 antagonist) on FPS. All drugs were administered bilaterally into the VTA (1.0 mu g/0.2 mu l/site). Locomotor activity/exploration and motor coordination were evaluated in the open-field and rotarod tests. None of the drugs produced significant effects on FPS when injected before conditioning, indicating that VTA DA receptors are not involved in the acquisition of conditioned fear to a light-CS. In contrast, when injected before the test session, quinpirole significantly reduced FPS, whereas the other drugs had no effect. Quinpirole's ability to decrease FPS may be the result of an action on VTA D2 presynaptic autoreceptors that decrease dopamine levels in terminal fields of the mesocorticolimbic pathway. Altogether, the present results suggest the importance of VTA DA neurons in the fear-activating effects of Pavlovian conditioning. In addition to demonstrating the importance of dopaminergic mechanisms in the motivational consequences of footshock, the present findings also indicate that these neural circuits are mainly involved in the expression, rather than acquisition, of conditioned fear. (C) 2008 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 06/06354-5 - Psicobiologia do medo e da ansiedade
Beneficiário:Marcus Lira Brandão
Linha de fomento: Auxílio à Pesquisa - Temático