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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chicken Dapper Genes Are Versatile Markers for Mesodermal Tissues, Embryonic Muscle Stem Cells, Neural Crest Cells, and Neurogenic Placodes

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Autor(es):
Alvares, Lucia Elvira [1] ; Winterbottom, Farrah Leigh [2] ; Sobreira, Debora Rodrigues [1] ; Xavier-Neto, Jose [3] ; Schubert, Frank Richard [4] ; Dietrich, Susanne [5]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, Dept Histol & Embryol, Sao Paulo - Brazil
[2] Kings Coll London, Inst Dent, Dept Cranofacial Dev, London WC2R 2LS - England
[3] HC FMUSP, Lab Gen&oecutet & Cardiol Mol InCor, Sao Paulo - Brazil
[4] Univ Portsmouth, Sch Biol Sci, Inst Biomed & Biomol Sci, Portsmouth, Hants - England
[5] Kings Coll London, Sch Biomed & Hlth Sci, London SE1 1UL - England
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: DEVELOPMENTAL DYNAMICS; v. 238, n. 5, p. 1166-1178, MAY 2009.
Citações Web of Science: 8
Resumo

Dapper (Dpr) proteins are context-dependent regulators of Wnt and Tgf beta signaling. However, although inroads into their molecular properties have been made, their expression and biological function are not understood. Searching for avian Dpr genes, we found that the chicken harbors a Dpr1 and a Dpr2 paralogue only. The genes are expressed in distinct patterns at gastrulation, neurulation, and organogenesis stages of development with key expression domains being the posterior primitive streak, anterior node and notochord, presomitic mesoderm (segmental plate), lateral and cardiac mesoderm, limb mesenchyme, and neurogenic placodes for Dpr1, and anterior primitive streak, node, epithelial somites, embryonic muscle stem cells, oral ectoderm and endoderm, neural crest cells, limb ectoderm, and lung buds for Dpr2. Expression overlaps in a few tissues; however, in several tissues, expression is complementary. Developmental Dynamics 238:1166-1178, 2009. (C) 2009 Wiley-Liss, Inc. (AU)

Processo FAPESP: 06/05892-3 - Estudo das funções dos genes da família Frodo/Dapper na embriogênese dos vertebrados
Beneficiário:Lúcia Elvira Álvares
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 06/50843-0 - Evolução e desenvolvimento das câmaras cardíacas
Beneficiário:José Xavier Neto
Linha de fomento: Auxílio à Pesquisa - Regular