Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats

Texto completo
Autor(es):
Bassi, Gabriel S. [1, 2] ; Broiz, Ana C. [1, 2] ; Gomes, Margarete Z. [1, 2] ; Brandao, Marcus L. [2, 1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] INeC, BR-14040901 Ribeirao Preto, SP - Brazil
[2] FFCLRP, Lab Psicobiol, BR-14049901 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Psychopharmacology; v. 204, n. 1, p. 13-24, MAY 2009.
Citações Web of Science: 8
Resumo

Ultrasound vocalizations (USVs) at approximately 22 kHz are usual components of the defensive response of rats. However, depending on the neural substrate that is activated, such as the dorsal periaqueductal gray (dPAG), USV emissions may be reduced. Activation of neurokinin-1 (NK-1)-mediated mechanisms of the dPAG causes analgesia, reduced 22 kHz USVs, and anxiogenic-like effects in rats exposed to the elevated plus maze (EPM). Involvement of other types of neurokinin receptors in this activation has not yet been evaluated. The present study examined whether local injections of the selective NK-3 agonist senktide (1-100 pmol/0.2 mu L) into the dPAG can (1) cause anxiogenic effects in the EPM, (2) influence novelty-induced 22 kHz USVs, or (3) change nociceptive reactivity in the tail-flick test. Senktide elicited a significant increase in exploratory behavior, an effect accompanied by hyperalgesia and an increase in the number of 22 kHz USVs. The nociceptive effects, increased locomotor activity, and USV emissions elicited by local injections of senktide (50 pmol/0.2 mu L) were reduced by prior injections of the selective NK-3 receptor antagonist SB222200 (50 pmol/0.2 mu L) into the dPAG. These findings show that NK-3 receptors in the dPAG mediate nociceptive responses in this area, contrasting with the known fear-related processes mediated by NK-1 receptors in the dPAG. Both hyperalgesia and fear-related processes are accompanied by emissions of 22 kHz USVs. (AU)

Processo FAPESP: 06/06354-5 - Psicobiologia do medo e da ansiedade
Beneficiário:Marcus Lira Brandão
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 06/03930-5 - Inibição da resposta aversiva neurocininérgica na matéria cinzenta periaquedutal dorsal de ratos Wistar, através do bloqueio local de receptores NK1, avaliada pelo teste do labirinto em cruz elevado
Beneficiário:Gabriel Shimizu Bassi
Linha de fomento: Bolsas no Brasil - Iniciação Científica