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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus

Texto completo
Autor(es):
Iborra, R. T. [1] ; Ribeiro, I. C. D. [1] ; Neves, M. Q. T. S. [1] ; Charf, A. M. [1] ; Lottenberg, S. A. [1] ; Negrao, C. E. [2] ; Nakandakare, E. R. [1] ; Passarelli, M. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med Sci, Lipids Lab LIM 10, BR-01246000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Sci, Inst Heart, BR-01246000 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS; v. 18, n. 6, p. 742-750, DEC 2008.
Citações Web of Science: 33
Resumo

In this study, we analyzed the effect of aerobic exercise training (AET) and of a single bout of exercise on plasma oxidative stress and on antioxidant defenses in type 2 diabetes mellitus (DM) and in healthy control subjects (C). DM and C did not differ regarding triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, and HOMA index at baseline and after AET. To measure the lag time for low-density lipoprotein (LDL) oxidation (LAG) and the maximal rate of conjugated diene formation (MCD), participants' plasma HDL(2) and HDL(3) were incubated with LDL from pooled healthy donors' plasma. In the presence of HDL(3), both LAG and MCD were similar in C and DM, but only in DM did AET improve LAG and reduce MCD. In the presence of HDL(2), the lower baseline LAG in DM equaled C after AET. MCD was unchanged in DM after AET, but was lower than C only after AET. Furthermore, after AET plasma thiobarbituric acid-reactive substances were reduced only in DM subjects. Despite not modifying the total plasma antioxidant status and serum paraoxonase-1 activity in both groups, AET lowered the plasma lipid peroxides, corrected the HDL(2), and improved the HDL(3) antioxidant efficiency in DM independent of the changes in blood glucose, insulin, and plasma HDL concentration and composition. (AU)

Processo FAPESP: 03/02266-6 - Efeito do treinamento físico aeróbio intenso sobre a oxidação de lipoproteínas (in vivo e in vitro) e a remoção de lípedes celulares, mediada por HDL, no diabete melito tipo 2
Beneficiário:Rodrigo Tallada Iborra
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 05/55249-7 - Efeito do treinamento físico aeróbio intenso, no Diabete melito tipo 2, sobre a oxidação de lipoproteínas e as propriedades antiaterogênicas das HDL: defesa antioxidante e remoção de colesterol celular
Beneficiário:Marisa Passarelli
Linha de fomento: Auxílio à Pesquisa - Regular