Distribution of small Rho GTPases in the developing rat submandibular gland

Autor(es)

Crema, Virginia O. ^{[1, 2]} ; Fossati, Anna Christina M. ^[3] ; Hamassaki, Dania E. ^[1] ; Santos, Marinilce F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Cell & Dev Biol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil

^[2] Univ Fed Triangulo Mineiro, Dept Biol Sci, Uberaba, MG - Brazil

^[3] Univ Fed Rio Grande do Sul, Sch Dent, BR-90035003 Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Histology; v. 39, n. 5, p. 519-525, OCT 2008.
• Citações Web of Science: 8

Resumo

During the rat submandibular gland (SMG) development, organogenesis and cytodifferentiation depend on the actin cytoskeleton, which is regulated by small Rho GTPases. These proteins link cell surface receptors to pathways that regulate cell motility, polarity, gene expression, vesicular trafficking, proliferation and apoptosis. The aim of this study was to evaluate, by immunohistochemistry, the distribution pattern of RhoA, RhoB, RhoC, Rac1 and Cdc42 during cytodifferentiation of the rat SMG and in male adults. All GTPases were found in epithelial and mesenchymal tissues throughout gland development. Rac1 appeared to be important for parenchyma expansion at the beginning of cytodifferentiation, while RhoC, Cdc42 and the inactive phosphorylated form of Rac1 seemed associated with lumen formation and cell polarization in terminal tubules. RhoA and RhoB labeling was evident throughout development. All GTPases were differentially expressed in the adult gland, suggesting that they play specific roles during differentiation and function of the rat SMG. (AU)

• Processo FAPESP: 06/57508-2 - Mecanismos de sinalização envolvidos na hiperglicemia crônica: efeitos sobre a migração celular
• Beneficiário: Marinilce Fagundes dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 01/09047-2 - Desenvolvimento e degeneração da retina de vertebrados: aspectos celulares e moleculares
• Beneficiário: Dania Emi Hamassaki
• Modalidade de apoio: Auxílio à Pesquisa - Temático