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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome

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Autor(es):
Borges, Alessandra Abel [1, 2] ; Campos, Gelse Mazzoni [1] ; Moreli, Marcos Lazaro [1] ; Moro Souza, Ricardo Luiz [1] ; Saggioro, Fabiano Pinto [3] ; Figueiredo, Glauciane Garcia [1] ; Livonesi, Marcia Cristina [1] ; Moraes Figueiredo, Luiz Tadeu [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ S Santa Catarina UNISUL, Sch Med, Virol Res Unit, BR-88704900 Tubarao, Santa Catarina - Brazil
[3] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Microbes and Infection; v. 10, n. 10-11, p. 1150-1157, AUG-SEP 2008.
Citações Web of Science: 36
Resumo

The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-beta observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients. (c) 2008 Elsevier Masson SAS. All rights reserved. (AU)

Processo FAPESP: 02/14149-1 - Análise de polimorfismo genético nos pacientes com Síndrome Pulmonar e Cardiovascular por Hantavirus e estudo de sua patogênese
Beneficiário:Alessandra Abel Borges
Linha de fomento: Bolsas no Brasil - Doutorado