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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Congenital Bilateral Perisylvian Syndrome: Familial Occurrence, Clinical and Psycholinguistic Aspects Correlated with MRI

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Autor(es):
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Brandao-Almeida, I. L. [1] ; Hage, S. R. V. [2] ; Oliveira, E. R. M. ; Guimaraes, C. A. ; Teixeira, K. C. S. ; Abramides, D. V. M. [2] ; Montenegro, M. A. ; Santos, N. F. [1] ; Cendes, F. ; Lopes-Cendes, I. [1] ; Guerreiro, M. M. [3]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Med Genet, BR-13083970 Campinas, SP - Brazil
[2] Univ Sao Paulo FOB, Dept Speech Pathol, Bauru, SP - Brazil
[3] Univ Estadual Campinas, Dept Neurol, FCM, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: NEUROPEDIATRICS; v. 39, n. 3, p. 139-145, JUN 2008.
Citações Web of Science: 8
Resumo

Objective: Congenital bilateral perisylvian syndrome (CBPS) is frequently caused by polymicrogyria (PMG). The aim of this study was to correlate the clinical and psycholinguistic aspects with neuroradiological data of patients with CBPS. Methods: Thirty-one patients were studied. We performed a clinical investigation of the patients and their families, including MRI scanning, neuropsychological tests and language evaluation. Results: The statistical analysis showed that: a) prenatal events are associated with the non-familial type of PMG; b) diffuse PMG is associated with pseudobulbar signs, as opposed to BPPP; c) motor deficit is associated with diffuse PMG; d) epilepsy is equally present in patients with both familial or non-familial PMG, but is more frequently seen in patients with diffuse PMG; e) dyslexia and SLI can be a feature of both the diffuse or BPPP, and either familial or sporadic cases of PMG. Conclusions: The severity of clinical manifestations in CBPS is correlated with the extent of cortical involvement. Most patients with CBPS have a history of speech delay or language difficulties and no epilepsy. Dyslexia can be found in patients with PMG. (AU)

Processo FAPESP: 03/01264-0 - Estudo molecular e de correlação genótipo-fenótipo na polimicrogiria perisylviana bilateral congênita
Beneficiário:Iara Leda Brandao de Almeida
Linha de fomento: Bolsas no Brasil - Doutorado