Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fenvalerate, A Pyrethroid Insecticide, Adversely Affects Sperm Production and Storage in Male Rats

Texto completo
Autor(es):
Arena, Arielle C. [1] ; Fernandez, Carla D. B. [1] ; Porto, Elaine M. [1] ; Bissacot, Denise Z. [2] ; Pereira, Oduvaldo C. M. [3] ; Kempinas, Wilma G. [4]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, Dept Biol Celular, Campinas, SP - Brazil
[2] UNESP, CEATOX, Inst Biociencias, BR-18618000 Botucatu, SP - Brazil
[3] UNESP, Dept Farmacol, Inst Biociencias, BR-18618000 Botucatu, SP - Brazil
[4] UNESP, Dept Morfol, Inst Biociencias, BR-18618000 Botucatu, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES; v. 71, n. 23, p. 1550-1558, 2008.
Citações Web of Science: 40
Resumo

The aim of this study was to investigate the potential estrogenic activity of fenvalerate by examining reproductive and fertility capabilities in Wistar rats. Adult male animals were treated for 30 d with 20 or 40 mg/kg/d fenvalerate or corn oil (vehicle) by oral gavage. Further, a possible estrogenic activity of fenvalerate (0.4, 1, 4, 8, or 40 mg/kg) was tested after a 3-d treatment of immature female rats using the uterotrophic assay. Exposure to the higher dose of fenvalerate was toxic to testis and epididymis as shown by a decrease in the absolute weights and sperm counts in both organs. Although the sperm counts were reduced, the fertility and sexual behavior were similar in control rats and rats treated with 40 mg/kg pesticide. Fenvalerate did not exert estrogenic activity in vivo at the tested doses. Data suggest that fenvalerate treatment in this study failed to compromise fertility, possibly due to enhanced reproductive capacity in rodents compared to humans. (AU)

Processo FAPESP: 04/08627-3 - Melhoria das condições de experimentação no biotério de pequenos mamíferos: aquisição e instalação de uma autoclave de grande porte
Beneficiário:Wilma de Grava Kempinas
Linha de fomento: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
Processo FAPESP: 02/09455-6 - Parâmetros reprodutivos masculinos e fertilidade de ratos adultos expostos ao inseticida piretróide fenvalerato
Beneficiário:Arielle Cristina Arena
Linha de fomento: Bolsas no Brasil - Doutorado