Diabetic Peripheral Neuropathies: A Morphometric Overview

Autor(es)

Sassoli Fazan, Valeria Paula ^{[1, 2]} ; Carvalho de Vasconcelos, Carlos Augusto ^{[3, 4]} ; Valenca, Marcelo Moraes ^[4] ; Nessler, Randy ^[1] ; Moore, Kenneth Charles ^[1]

Afiliação do(s) autor(es)

^[1] Univ Iowa, Cent Microscopy Res Facil, Iowa City, IA 52241 - USA

^[2] USP, Sch Med Ribeirao Preto, Dept Surg & Anat, BR-14049900 Ribeirao Preto, SP - Brazil

^[3] Univ Fed Pernambuco, Elect Microscopy Sect, LIKA, Recife, PE - Brazil

^[4] Univ Fed Pernambuco, Div Neurol & Neurosurg, Dept Neuropsychiat, BR-50670901 Recife, PE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF MORPHOLOGY; v. 28, n. 1, p. 51-64, MAR 2010.
• Citações Web of Science: 7

Resumo

Diabetes is now considered one of the main threats to human health in the 21st century and many researchers are dedicated to investigate the physiopathology of the disease, with further insights on the managements of its major complications. Since understanding the pathophysiology of the major complications of diabetes and their underlying processes is mandatory, experimental models of the disease may be useful as they allow the recognition of the early mechanisms involved in the long-term complications of diabetes. Peripheral nerve involvement is highly frequent in diabetes mellitus and it has been documented that one third of diabetic patients have peripheral neuropathy. The true prevalence is not known and reports vary from 10% to 90% in diabetic patients, depending on the criteria and methods used to define neuropathy. In this review, the most common experimental models of diabetes are presented and the pathological findings on major peripheral nerves are discussed. Also, the insights brought by morphometry to the diabetic neuropathy research are highlighted. (AU)

• Processo FAPESP: 06/06362-8 - Avaliação morfológica ultraestrutural das alterações do nervo renal de ratos diabéticos induzidos experimentalmente
• Beneficiário: Valéria Paula Sassoli Fazan
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 04/09139-2 - Estudos morfofuncionais e morfométricos do sistema nervoso central e periférico e do sistema cardiovascular, envolvidos na regulação neuro-humoral de funções neurovegetativas e comportamentais
• Beneficiário: Helio Cesar Salgado
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 06/03200-7 - Estudo morfológico e morfométrico do nervo sural de ratos normotensos, espontaneamente hipertensos (SHR) e espontaneamente hipertensos com diabete induzido experimentalmente
• Beneficiário: Valéria Paula Sassoli Fazan
• Modalidade de apoio: Auxílio à Pesquisa - Regular