Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ruthenium (II) phosphine/picolinate complexes as antimycobacterial agents

Texto completo
Autor(es):
Pavan, Fernando R. [1] ; Von Poelhsitz, Gustavo [2] ; do Nascimento, Fabio B. [3] ; Leite, Sergio R. A. [4] ; Batista, Alzir A. [3] ; Deflon, Victor M. [5] ; Sato, Daisy N. [6] ; Franzblau, Scott G. [7] ; Leite, Clarice Q. F. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil
[2] Univ Fed Goias, Dept Quim, BR-75704020 Catalao, Go - Brazil
[3] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[4] Univ Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP - Brazil
[5] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
[6] Inst Adolfo Lutz Registro, Unidade Ribeirao Preto, BR-14085410 Ribeirao Preto, SP - Brazil
[7] Univ Illinois, Coll Pharm, Inst TB Res, Chicago, IL - USA
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 45, n. 2, p. 598-601, FEB 2010.
Citações Web of Science: 35
Resumo

The synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis-{[}Ru(pic)(dppm)(2)]PF(6) (1), Cis- {[}Ru(pic)(dppe)(2)]PF(6) (2) and {[}Ru(pic)(2)(PPh(3))(2)] (3) {[}pic = 2-pyridinecarboxylate; dppm = bis(diphenylphosphino)methane: dppe = 1,2-bis(diphenylphosphino)ethane; PPh(3) = triphenylphosphine] are reported in this article. The complexes were characterized by elemental analysis, spectroscopic and electrochemical techniques. Their in vitro anti mycobacterial activity was determinated as the Minimum Inhibitory Concentration (MIC) for MTB cell growth, measured by the REMA method. The best MICs were found for complexes (1) and (2), with values of 0.78 and 0.26 mu g/mL, respectively. The results are comparable to or better than ``first line{''} or ``second line{''} drugs commonly used in the treatment of TB. (C) 2009 Elsevier Masson SAS. All rights reserved. (AU)

Processo FAPESP: 08/10390-2 - Determinação do perfil pré-clínico da atividade antituberculose in vitro e in vivo dos complexos de rutênio(II)fosfinas / diiminas
Beneficiário:Fernando Rogério Pavan
Linha de fomento: Bolsas no Brasil - Doutorado